Geriatric Nutritional Risk Index (GNRI) is independently associated with postoperative complications, pathological complete response prediction, and prognostication in neoadjuvant immunotherapy-treated esophageal squamous cell carcinoma. Higher GNRI correlates with increased pathological complete response rates, decreased severe morbidity, and improved 3-year overall and disease-free survival. GNRI, utilizing nutrition-related indicators, serves as a valuable tool for risk assessment […]
Category: Upper Gastrointestinal Tract
Understanding Upper Gastrointestinal and Hepatopancreaticobiliary Surgery in New Zealand
New Zealand is a low-volume center for upper gastrointestinal surgery, with most complex procedures concentrated in national cancer centers. There is evidence of regionalization, where larger centers perform procedures more frequently. Palliative procedures are more widely performed, but indigenous Māori are less likely to be treated in designated cancer centers. The challenge lies in optimizing […]
Hyperthermic Intraperitoneal Chemotherapy Improves Survival in Gastric Cancer Patients
Hyperthermic intraperitoneal chemotherapy (HIPEC) significantly improved overall survival and reduced recurrence rates in both prophylactic and therapeutic settings for peritoneal carcinomatosis of gastric origin. This systematic review and meta-analysis of randomized trials highlights the efficacy of HIPEC as a safe and effective tool for prophylaxis and a promising resource for treatment, emphasizing the need for […]
Comparison of Stapled vs Handsewn Anastomosis and Anastomotic Leaks in Gastric Cancer Surgery
Results showed no significant association between stapled or handsewn anastomosis and anastomotic leaks in gastric cancer surgery. This population-based study included 2164 patients in Finland, with 21.8% having handsewn anastomosis and 78.2% having stapled anastomosis. Regardless of the type of gastrectomy, the choice of anastomotic technique did not impact the occurrence of leaks. Journal Article […]
High En-bloc and R0 Resection Rates in Esophageal Cancer
Esophageal cancer patients who underwent endoscopic submucosal dissection (ESD) for T1B tumors showed high en-bloc (100%) and R0 (82.3%) resection rates. Only 23.5% experienced tumor recurrence post-ESD, with safer outcomes in patients receiving additional therapies. Larger studies are necessary to confirm the long-term efficacy of ESD in T1B esophageal cancer. Journal Article by Youssef M, […]
Prognostic Value of Cachexia Index in Oesophagogastric Cancer Patients
A novel prognostic marker, the cachexia index (cxi), is associated with disease progression, postoperative mortality, and overall survival in patients with locally advanced oesophagogastric cancer. Patients with low cxi had higher rates of disease progression, worse postoperative mortality, and decreased overall survival compared to those with normal cxi values. The cxi measurement could aid in […]
13.3% Incidence and Spontaneous Resolution of Gas-Bloat Syndrome Post-Magnetic Sphincter Augmentation
Gas-Bloat Syndrome affects 13.3% of patients at 1 year post-Magnetic Sphincter Augmentation, resulting in worse GERD-HRQL scores, medication use, and satisfaction. However, it resolves spontaneously in the majority of cases, leading to quality-of-life improvement. Patients with preoperative bloating, high GERD-HRQL scores, or smaller device size are at increased risk. Journal Article by Eriksson SE, Ayazi […]
Frailty and TG/PG Increase Risk of Postoperative Pneumonia in Gastric Cancer Patients
Frailty and total or proximal gastrectomy (TG/PG) were found to be independent risk factors for postoperative pneumonia (POP) in patients with gastric cancer undergoing gastrectomy. A simple risk assessment method combining these factors effectively predicted and prepared patients for POP, with a 5.5% incidence rate and an area under the receiver operating characteristic curve of […]
Validation of Textbook Outcome Parameter in Esophageal Cancer Surgery
This study validates textbook outcome (TO) as a quality performance indicator (QPI) for esophageal cancer surgery. Postoperative complications, including Clavien-Dindo grade ≥3 complications, and 30-day readmission rate are associated with reduced survival. Updating TO parameters to include severe complications strengthens its association with increased survival, suggesting the need for a more precise QPI definition in […]
Development of a Nomogram for Preoperative Estimation of Splenic Hilar Lymph Node Metastasis
A high-performing preoperative nomogram for predicting splenic hilar lymph node metastasis in non-greater curvature advanced proximal gastric cancer was developed. Tumor location, size, Borrmann type, and lymphadenectasis were key predictors. The nomogram showed good performance in both training and validation cohorts, aiding surgeons in making informed clinical decisions and leading to improved patient outcomes. Journal […]