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Assessment of tertiary lymphoid structures (TLSs) through a digital gene panel proved highly accurate in predicting TLS status and demonstrated associations with survival and response to anti-cancer therapies in gastric cancer patients. Patients with high TLS gene signature exhibited significant benefits from adjuvant chemotherapy and…
Researchers analyzed 623 esophageal squamous cell carcinoma (ESCC) patients post-neoadjuvant therapy, finding lymph node metastases in 34% of cases. Metastases were most frequent along the right recurrent nerve (10.1%), paracardial station (11.4%), and left gastric artery (10.9%). The data, differentiated by tumor location and pretreatment…
Endoscopic submucosal dissection (ESD) yields superior en bloc resection, higher R0 resection, and curative resection rates compared to endoscopic mucosal resection (EMR) for Barrett's neoplasia and esophageal adenocarcinoma. ESD also shows lower local recurrence rates. Adverse events between the two techniques were similar. These findings…
Proximal gastrectomy with double-tract reconstruction leads to lower glucose variability postoperatively compared to total gastrectomy. Patients who underwent the procedure exhibited smaller fluctuations in glucose levels and experienced fewer dumping symptoms. Food flow into the remnant stomach was crucial for maintaining better glycemic control and…
A novel oral-vestibule-enteral anastomosis (OVEA) technique shows promise in patients with compromised epiglottic function or esophageal loss, providing a solution where traditional surgeries fail. Outcomes from 13 patients revealed successful oral feeding, improved quality of life, and minimal fatalities, highlighting the potential of OVEA to…
Preoperative laboratory data indicators, including the systemic immune-inflammation index (SII) and prognostic nutritional index (PNI), were found to significantly impact overall survival in patients with postoperative staged T3N0M0 esophageal carcinoma. These indicators, along with the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR),…
Robotic gastrectomy (RG) demonstrated higher overall survival, lower postoperative complications, faster recovery, and other advantages compared to laparoscopic gastrectomy (LG) in gastric cancer patients. While mortality and disease-free survival were similar between the two techniques, RG offered better outcomes in specific scenarios like intracorporeal reconstruction…
Malignancies in the upper gastrointestinal tract can be effectively treated through endoscopic resection at an early stage. Key factors influencing successful resection include thorough pre-resection assessment, precise delineation of margins, and selection of appropriate resection techniques. This review outlines clinical algorithms for the endoscopic resection…
In minimally invasive upper gastrointestinal and bariatric surgery, a trocar-less elastic intra-corporeal retractor (icr) was developed and proven effective in liver retraction. The icr is safe, inexpensive, and easily reproducible, reducing risks of bleeding, infection, and liver injury associated with conventional methods. It offers quick…
This study developed and validated a new lymph nodal staging system for pt3-4n0-2m0 gastric cancer patients. The new classification, based on examined lymph nodes and lymph node ratio, outperformed the current system in prognostic prediction accuracy. The improved staging method emerged as an independent prognostic…
