Category: Upper Gastrointestinal Tract

PORSHA for Paraesophageal Hernias: Phase 2a Results

Posterior Rectus Sheath Hiatal Flap Augmentation (PORSHA) exhibits promise as a surgical innovation for large and recurrent paraesophageal hernias. In a study of 27 cases, PORSHA, after technical modifications, demonstrated safety and success in repairing type III, IV, and recurrent paraesophageal hernias. At an 11-month follow-up, there were no radiologic recurrences, abdominal eventrations, or hernias […]

TSLG versus LTH for Siewert Type II AEG: Advantages and Efficacy

Transthoracic single-port-assisted laparoscopic gastrectomy (TSLG) demonstrates technical safety and feasibility in comparison to laparoscopic transhiatal approach (LTH) for Siewert type II adenocarcinoma of the esophagogastric junction. In a retrospective study, TSLG showed advantages, including increased harvested lymph nodes, reduced lower mediastinal lymph nodes, and longer proximal margins. The R0 gastrectomy rate was higher in the […]

Recurrence-Free Survival Strongly Correlates with Overall Survival in Neoadjuvant-Treated Oesophageal Squamous Cell Carcinoma

Recurrence-free survival is a valid surrogate endpoint for overall survival in surgically resectable advanced oesophageal squamous cell carcinoma (oscc) patients receiving neoadjuvant chemotherapy. A strong correlation (kendall’s τ 0.797) was found between the two endpoints, particularly in patients with a more favorable response to neoadjuvant treatment. This suggests that recurrence-free survival can be used as […]

Metastatic Lymph Nodes and Survival in Esophageal Cancer

Patients with 1 metastatic lymph node had a median overall survival of 49.8 months, while those with 2 metastatic lymph nodes had an overall survival of 33.3 months. Survival was not significantly different between patients with 1 metastatic lymph node in 1 lymph node metastasis station and those with 2 metastatic lymph nodes in the […]

Long-Term Oncologic Outcome Similar Between Proximal Gastrectomy and Total Gastrectomy for Upper-Third AGC and EGJ Cancer

Proximal gastrectomy (PG) and total gastrectomy (TG) for upper-third advanced gastric cancer (AGC) and Siewert type II esophagogastric junction (EGJ) cancers yield similar overall survival rates (61.7% vs. 68.3%) and recurrence-free survival rates (86.7% vs. 83.3%). PG group had eight recurrences, but operation method was not identified as a prognostic factor of tumor recurrence in […]

Feasibility and Safety of Minimally Invasive Gastrectomy Post-Chemotherapy

Examining minimally invasive gastrectomy post-preoperative chemotherapy for advanced gastric cancer, this study included 150 patients, assessing safety and feasibility. The overall morbidity rate was 12%, with a higher incidence in total/proximal gastrectomy plus splenectomy cases. Robotic gastrectomy, especially in cases involving splenectomy, demonstrated significantly lower postoperative complications compared to the laparoscopic approach. The findings support […]

Elective Laparoscopic Repair Improves Life Expectancy in Paraesophageal Hernia

Researchers utilized an updated Markov model to compare life-years gained with elective laparoscopic paraesophageal hernia repair (ELHR) versus watchful waiting (WW) in patients aged 40-90 with symptoms, Cameron lesions, or comorbid conditions. ELHR was found to increase life expectancy over WW in most cases, particularly in symptomatic patients. Despite the impact of comorbidities, ELHR remained […]

Mesh type does not significantly impact long-term hernia recurrence after laparoscopic cruroplasty

Among 2170 patients undergoing laparoscopic hiatal hernia repair with follow-up, objective recurrence rates were 20.8% with suture repair, 20.6% with absorbable mesh, 13.7% with non-absorbable mesh, and 0% with partially absorbable mesh. Despite initial favor for non-absorbable mesh in the mid-term, all mesh types showed similar long-term recurrence rates (≥48 months). Mesh type did not […]

Early-onset adenocarcinoma of esophagogastric junction shows significantly better postoperative survival compared to late-onset adenocarcinoma

Results from a population-based study comparing early-onset and late-onset adenocarcinoma of esophagogastric junction demonstrated significantly better overall and cancer-specific survival in early-onset cases. Kaplan-Meier curves, multivariate Cox regression analyses, propensity score matching, and competing risk models all consistently showed a more favorable prognosis in early-onset adenocarcinoma patients. Journal Article by Chen L, Jin T (…) […]

Surgery Prevails in Second Primary Esophageal Cancer

Survival benefit of surgery for second primary esophageal cancer following gastrointestinal cancer is significant. Surgery, year of diagnosis, regional lymph node surgery scope, tumor differentiation grade, SEER historic stage, and triple therapy are independent prognostic factors. In a cohort study of 582 patients, surgery significantly improved survival outcomes compared to no surgery or chemoradiotherapy. These […]