Researchers conducted a study to develop and validate a nomogram for predicting overall survival (OS) in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Using data from the SEER registry, they identified key prognostic factors and compared the nomogram’s performance to the AJCC staging system. The results showed that the nomogram, which combined treatment data, had a […]
Category: Upper Gastrointestinal Tract
Improved ypStage Grouping System for Esophageal Squamous Cell Carcinoma Patients
A revised ypStage grouping system was proposed for esophageal squamous cell carcinoma patients who underwent neoadjuvant chemoradiotherapy followed by surgery. The new system adequately addressed the limitations of the existing American Joint Committee on Cancer (AJCC) system, showing improved prognostic relevance and higher discrimination ability. The study cohort included 501 patients in the development cohort […]
Book-Binding Technique (BBT) Shows Safe Intracorporeal Gastroduodenostomy in Totally Laparoscopic Distal Gastrectomy for Gastric Cancer
The book-binding technique (BBT) is a safe and feasible method for intracorporeal gastroduodenostomy in totally laparoscopic distal gastrectomy (TLDG) for patients with gastric malignancy. This retrospective study evaluated 188 patients who underwent TLDG with BBT reconstruction, showing low rates of anastomotic stenosis and leakage. The median time to the first diet was 3.1 days, and […]
Cost-Effective Management of Locally Advanced Gastric Cancer: Preoperative Chemotherapy Dominates
Based on a cost-effectiveness analysis, researchers found that PCT is the most cost-effective management modality for LAGC compared to upfront surgery (US). PCT yielded 3.11 quality-adjusted life-years (QALYs) at a cost of $40,792.16, while US yielded 3.15 QALYs at a cost of $55,575.57. The incremental cost-effectiveness ratio (ICER) was $369,585.25. Sensitivity analyses consistently favored PCT, […]
Long-term Oncological Outcomes of Robotic and Laparoscopic Gastrectomy for Gastric Cancer
The multicentre cohort study aimed to compare the long-term oncological outcomes between robotic gastrectomy (RG) and laparoscopic gastrectomy (LG) for patients with gastric cancer. The study included a total of 2,055 patients who underwent RG and 4,309 patients who underwent LG. After matching the patients using propensity scores, the study found that RG and LG […]
The Impact of Socioeconomic Deprivation on Access to Guideline-Concordant Treatment in Foregut Cancer
High socioeconomic deprivation, as measured by the area deprivation index (ADI), significantly reduces the likelihood of receiving guideline-concordant treatment (GCT) for foregut cancers. In a retrospective study of 498 patients, 66% received GCT, with lower rates observed in pancreatic, gastric, and hepatobiliary cancers. Factors independently associated with non-receipt of GCT included age ≥75 years, black […]
Higher 30-day surgical complications observed in Asian Americans after esophagectomy
Asian Americans face higher 30-day surgical complications following esophagectomy compared to Caucasians, according to a retrospective analysis of the ACS-NSQIP database. The study found that Asian Americans had a greater likelihood of pulmonary complications, particularly pneumonia, renal dysfunction, including progressive renal insufficiency, and bleeding events. They also had a longer length of stay. These findings […]
Limited peritoneal disease progression in gastric cancer patients: No survival benefit with gastrectomy + cytoreductive surgery and HIPEC
The study aimed to evaluate the impact of gastrectomy with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on the outcomes of gastric cancer (GC) patients with limited peritoneal disease progression following neoadjuvant chemotherapy (NAC). Results showed that there was no survival benefit among advanced GC patients with peritoneal metastasis (PM) who underwent gastrectomy with […]
Comparable Outcomes of Gastric Bypass and Fundoplication for GERD in Patients with Obesity
A retrospective study compared the outcomes of Roux-en-Y gastric bypass and fundoplication in patients with obesity and gastroesophageal reflux disease (GERD). Ninety-five patients with a BMI ≥35 underwent either procedure. Both groups saw an improvement in GERD symptoms and overall quality of life. There were no significant differences in postoperative reflux symptoms, dysphagia, or overall […]
Procedure-specific Risks of Thrombosis and Bleeding in Abdominal Surgery Vary Significantly
This systematic review and meta-analysis of 285 studies, including over 8 million patients, evaluated the procedure-specific risks of symptomatic venous thromboembolism (VTE) and major bleeding in general abdominal, colorectal, upper gastrointestinal, and hepatopancreatobiliary surgeries. The risk of VTE varied widely among procedures, with VTE rates ranging from