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CRS Plus HIPEC Outperforms CRS Alone in Quality of Life for Cancer Patients

Patients with colorectal cancer receiving cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS plus HIPEC) experience significantly improved quality of life (QoL) compared to those undergoing CRS alone. Results indicate a notable minimal clinically important difference (MCID) favoring the HIPEC group, with improvement often evident within three months. Deterioration in MCID correlates with factors such as surgical approach, age, sex, and preoperative QoL, underscoring the importance of tailored preoperative strategies.

Journal Article by Chiu CC, Hsieh MC, Wang GL and Shi HY in Ann Surg Oncol

© 2025. Society of Surgical Oncology.

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Expert Consensus Establishes Guidelines for Sleeve Gastrectomy Practices

An international panel reached a consensus on sleeve gastrectomy, endorsing its use for diverse patient populations, including adolescents and the elderly. Key recommendations included avoiding routine dissection of the hiatus and prioritizing endoscopic pigtail drainage for managing acute leaks. Additional surgical options were outlined for patients with severe gastroesophageal reflux disease (GERD) and inadequate weight loss. Overall, the review highlights the procedure’s evolution as both safe and validated in clinical practice.

Journal Article by Nocca D, Gagner M (…) Nedelcu M et 2 al. in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Indocyanine Green Imaging Enhances Long-Term Survival in Gastric Cancer Surgery

In a pivotal 5-year follow-up of the FUGES-012 trial, patients who underwent indocyanine green (ICG) fluorescence-guided laparoscopic lymphadenectomy for gastric cancer exhibited significantly improved overall survival and disease-free survival compared to the non-ICG cohort. The ICG group also showed fewer recurrences, with a notable reduction in locoregional recurrences and an earlier recurrence peak in the non-ICG group. These findings advocate for ICG’s routine use in surgical settings.

Randomized Controlled Trial by Zhong Q, Wu D (…) Huang CM et 14 al. in BMC Med

© 2025. The Author(s).

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Advanced dynamic models improve survival predictions in colorectal cancer liver metastases

Dynamic prognostic models for colorectal cancer with liver metastases significantly enhance survival predictions by integrating longitudinal laboratory markers. In a cohort of 976 patients, the most effective model outperformed static approaches, achieving area under the curve (AUC) values of 0.850 for five-year progression-free survival and 0.849 for overall survival. A web-based tool has been developed to apply these models clinically, allowing for real-time adjustments based on evolving patient data.

Journal Article by Chen Q, Deng Y (…) Zhao H et 4 al. in JAMA Netw Open

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Real-time lymphatic mapping could redefine colon cancer surgery margins

A phase II trial aims to assess the effectiveness of indocyanine green (ICG) fluorescence-guided lymph node mapping in determining bowel resection margins for patients with colon cancer. By tailoring lymph node dissection based on individual anatomy, the approach seeks to balance extensive dissection and potential complications while optimizing oncological outcomes. If sensitivity exceeds 96% after 101 cases, ICG mapping may offer a new standard for personalized surgical margins in colon cancer interventions.

Journal Article by Panaiotti L, Karachun A, Muravtseva A and Petrov A in Int J Surg Protoc

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Prehabilitation Program Cuts Postoperative Complications for Sarcopenic Liver Surgery Patients

A 6-week multimodal prehabilitation program significantly slashed postoperative morbidity in patients with sarcopenia undergoing major hepatectomy. The prehabilitation group experienced a mere 13.3% complication rate compared to 50% in the standard care arm, translating to a 36.7% absolute risk reduction. All major complications occurred in the control group. Beyond lowering complications, the program also enhanced muscle mass and strength, underscoring the potential of exercise and nutrition in preoperative care.

Journal Article by Berardi G, Cucchetti A (…) Ettorre GM et 11 al. in JAMA Surg

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Salivary Pepsin Testing Reveals Key Reflux Factors Post-Esophagectomy

Salivary pepsin testing objectively tracks reflux trajectories in post-esophagectomy patients. The study identifies redundancy of conduit as a significant risk factor for increased reflux, while maintaining a semi-fowler position and pre-sleep fasting for at least two hours offers protective benefits. These findings highlight essential modifiable elements that can enhance recovery pathways for patients, aiming to mitigate a common yet challenging postoperative complication.

Journal Article by Yu Y, Yu F (…) Li Y et 13 al. in Ann Surg Oncol

© 2025. Society of Surgical Oncology.

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Robotic NICE procedure cuts costs in colorectal surgery significantly

The robotic NICE procedure delivers superior cost-effectiveness in left-sided colorectal resections, showing a median direct cost of $9,946—well below laparoscopic ($16,389), robotic ($14,473), and open surgery ($10,427). Total costs mirror this trend, with NICE at $22,263, contrasted with $29,324 for laparoscopic, $32,908 for robotic, and $22,915 for open. Adjusted analyses reveal NICE results in up to $6,393 savings compared to laparoscopic options, underscoring its economic advantages and potential for better patient outcomes.

Journal Article by Bistre-Varon J, Elhadi M (…) Haas EM et 11 al. in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Mobile App Enhances Bowel Preparation Compliance and Quality for Colonoscopy

A mobile app for bowel preparation training outperformed standard instructions in ensuring compliance and quality among colonoscopy patients. In a trial of 160 adults, those using the app achieved a 94.9% adequacy rate compared to 83.8% for the control group. Compliance with dietary protocols also surged, and patients reported fewer difficulties. Anxiety levels, however, remained unchanged between groups. The results underscore the potential of mobile health tools in improving pre-procedural education.

Journal Article by Şengör K, Keskin M and Akyüz N in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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New lymph node classification systems outperform AJCC in predicting gastric cancer survival

Log odds of positive lymph nodes (lodds) and positive lymph node ratio (lnr) demonstrate superior predictive capabilities for survival in gastric signet ring cell carcinoma (gsrc) patients compared to the traditional AJCC n-category. Multivariate analysis reveals both lodds and lnr as significant prognostic factors, with improved sensitivity and specificity in predicting outcomes at 1, 3, and 5 years. Their robust performance suggests they could replace the n-category for better survival risk assessment in clinical applications.

Journal Article by Wang LF, Sun ML (…) Chen YR et 4 al. in World J Surg Oncol

© 2025. The Author(s).

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