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Bariatric surgery reduces risks in obese patients with CKD

In a comprehensive study of 5,221 adults with obesity and chronic kidney disease (CKD), bariatric metabolic surgery (BMS) demonstrated a significantly reduced risk of major adverse cardiovascular events, major adverse kidney events, and all-cause mortality over five years. The protective effects of BMS were consistent across all CKD stages but were notably stronger in patients with advanced CKD. Additionally, BMS led to better preservation of kidney function compared to nonsurgical management, showcasing its potential advantage in high-risk populations.

Journal Article by Lin YM, Kao CL (…) Wu JY et 4 al. in Obes Surg

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Advances in Third-Space Endoscopy Improve GI Tumor Management

A review highlighted significant advancements in third-space endoscopy techniques for gastrointestinal tumors. Submucosal tunneling endoscopic resection (STER) was found to be safe and effective, achieving high en bloc resection rates and reduced recovery times. Tunneling endoscopic submucosal dissection (ESD) variants also enhance outcomes for early neoplasms by improving dissection speed and minimizing adverse events. Incorporating these methods with personalized risk assessments could optimize treatment strategies, paving the way for future innovations in minimally invasive interventions.

Journal Article by Nabi Z and Reddy DN in Curr Opin Gastroenterol

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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AI-assisted system effectively aids esophageal lesion resections

The implementation of an artificial intelligence (AI) lesion-labeling system significantly improved the complete resection rate during endoscopic submucosal dissection (ESD) in low-volume centers. In a study involving 174 patients, 90% achieved negative lateral margins, while the en bloc resection rate stood at 98.5%. Comparatively, no significant difference was found in the lateral resection rates between AI-assisted and conventional groups, though the procedure duration was notably longer for the AI-assisted ESD.

Journal Article by Li B, Dong YL (…) Zhong YS et 10 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Size cut-offs established for rectal neuroendocrine neoplasm recurrence

A recent retrospective study involving 1,011 patients identified critical size thresholds for rectal neuroendocrine neoplasms (NENs). For grade 1 tumors, a 0.7 cm cut-off showed 100% sensitivity and 79% specificity, indicating minimal recurrence risk. Conversely, grade 1 tumors with lymphovascular invasion necessitated a 1.5 cm cut-off. Grade 2 NENs, which exhibited a 22.9% lymph node metastasis rate, require continual surveillance regardless of size. These insights aim to refine follow-up strategies for improved patient management.

Journal Article by Kim S, Kim ER (…) Cho YB et 9 al. in Dig Endosc

© 2025 The Author(s). Digestive Endoscopy published by John Wiley & Sons Australia, Ltd on behalf of Japan Gastroenterological Endoscopy Society.

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Laparoscopic appendectomy dominates treatment for acute appendicitis

In a comprehensive analysis of nearly 32,000 appendicitis cases in Germany, laparoscopic appendectomy emerged as the preferred surgical approach, conducted in 97% of cases by 2022. Complicated appendicitis was observed in 27.4% of patients, with variations in severity noted. Women showed a decreased likelihood of conversion to open surgery. The study highlighted that those who required an intraoperative switch faced higher morbidity risks, underscoring the importance of surgical technique in improving patient outcomes.

Multicenter Study by Schildberg C, Weber U (…) Mantke R et 5 al. in World J Emerg Surg

© 2025. The Author(s).

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CPZ demonstrates high sensitivity for diagnosing hepatocellular carcinoma

Carboxypeptidase Z (CPZ) emerges as a promising diagnostic biomarker for hepatocellular carcinoma (HCC), showing a remarkable 90.8% positive expression rate in a study of tumor tissues. In combination with other markers, CPZ achieved sensitivities up to 79.2% and specificities near 100%. Notably, it outperformed other markers in poorly differentiated HCC, suggesting its potential role in routine pathology. High accuracy was highlighted with an AUC of 0.908 for CPZ alone, underscoring its diagnostic value.

Journal Article by Deng M, Luo R (…) Hou Y et 8 al. in Am J Surg Pathol

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Sustainable surgical practices are achievable in resource-limited settings.

A case study on Kyabirwa Surgical Center in rural Uganda reveals that sustainable healthcare models can thrive in low-resource environments. From 2021 to 2023, only 0.4% of the center’s power and 25% of its water came from the town, yielding annual savings of over $6,121. The facility also effectively conserved 93% of collected rainwater and utilized environmentally friendly anesthesia alternatives in 71% of procedures. These findings advocate for global collaboration to enhance sustainable surgical care.

Journal Article by Travers G, Kibirango S (…) Marin M et 8 al. in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Lymphocyte-C-Reactive Protein Ratio Predicts Outcomes in Liver Cancer Surgery

A study examining 715 patients undergoing liver resection for hepatocellular carcinoma and intrahepatic cholangiocarcinoma found that the lymphocyte-C-reactive protein ratio (LCR) could accurately predict postoperative complications, recurrence-free survival, and overall survival. An optimal LCR cutoff of 6100 was established, with lower levels associated with increased morbidity and worse survival outcomes. The findings, validated in an independent cohort, suggest that preoperative LCR assessment can significantly enhance risk stratification for patients undergoing liver cancer surgery.

Journal Article by Altaf A, Baldo A (…) Pawlik TM et 22 al. in World J Surg

© 2025 The Author(s). World Journal of Surgery published by John Wiley & Sons Ltd on behalf of International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).

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RROM technique achieves low recurrence and minimal complications

The retro-rectus onlay mesh (RROM) technique for ventral hernia repair demonstrates notable long-term effectiveness. In a follow-up of over four years, a mere 0.38% recurrence rate was observed among 191 patients, alongside minimal complications, including four superficial infections. The method shows promise as a safe and cost-effective alternative to the standard intraperitoneal onlay mesh (IPOM) approach, addressing issues of mesh-bowel interaction and infection risk while improving outcomes in hernia care globally.

Journal Article by Jani K, Iyengar M and Shah MN in Hernia

© 2025. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature.

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Improved surgical quality significantly enhances pancreatic cancer survival

Achievements in textbook outcomes (TO) for pancreatic surgery rose from 47% to 80.7% post-establishment of a specialized unit, indicating better surgical quality. Patients who met TO criteria showed notable overall survival rates at 1, 2, and 3 years: 86.9%, 55.7%, and 41%, compared to 62.7%, 40.3%, and 31.3% for those who did not (p=.013). Multivariate analysis confirmed that fulfilling TO significantly lowers mortality risk (HR: 0.5; p=.004).

Journal Article by Sarriugarte Lasarte A, Marín Ortega H (…) Saa Álvarez R et 6 al. in Gastroenterol Hepatol

Copyright © 2025. Publicado por Elsevier España, S.L.U.

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