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Tumor marker clustering predicts hepatocellular carcinoma outcomes.

A multi-institutional study involving 1,515 hepatocellular carcinoma patients revealed that combining preoperative alpha-fetoprotein and des-gamma-carboxy prothrombin levels enables effective prognostic clustering. Patients in cluster 3 exhibited the worst five-year overall survival rate of 52.8% and a high recurrence rate of 79.3%. Conversely, cluster 4 showed superior outcomes with a 71.5% survival rate. Notably, des-gamma-carboxy prothrombin was a stronger overall survival predictor in patients with preserved liver function.

Journal Article by Saegusa Y, Imaoka Y (…) Ohdan H et 11 al. in J Gastrointest Surg

Copyright © 2025 Society for Surgery of the Alimentary Tract. Published by Elsevier Inc. All rights reserved.

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High success rate achieved in robotic-assisted esophagectomy

A significant 90% of patients achieved textbook outcomes following robotic-assisted minimally invasive esophagectomy (RAMIE) in a single-center analysis involving 150 consecutive patients. Key findings included a median hospital stay of 7 days, low mortality rates of 0.7% at 30 days and 1.3% at 90 days, and a complete pathologic response in 27% of patients. These results emphasize the effectiveness of robotic platforms and standardized techniques in enhancing postoperative outcomes for esophagectomy.

Journal Article by Kukar M, Jehan F (…) Hochwald SN et 2 al. in J Gastrointest Surg

Copyright © 2025. Published by Elsevier Inc.

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Robotic surgery reduces pancreatic fistula risk in high-risk patients

In a retrospective study involving 204 patients, robotic pancreatoduodenectomy (rpd) significantly lowered the incidence of clinically relevant postoperative pancreatic fistula (cr-popf) in high-risk patients compared to open pancreatoduodenectomy (opd). The cr-popf rate was 6.0% in the rpd group versus 38.2% in the opd group (p < 0.001). Moreover, multivariate analyses confirmed opd as an independent risk factor for cr-popf, with an odds ratio of 7.87, highlighting the advantages of robotic surgery in these complex cases.

Journal Article by Fuji T, Takagi K (…) Fujiwara T et 4 al. in Dig Surg

© 2025 S. Karger AG, Basel.

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Deep learning model enhances safety in laparoscopic gastrectomy

A deep learning-based model was developed for real-time recognition of perigastric blood vessels during laparoscopic radical gastrectomy. In testing, the model demonstrated high precision (mean 0.9442) and recall (mean 0.9099) for arteries and maintained robust performance across various challenging conditions. It showed potential to improve intraoperative safety and reduce the risk of accidental bleeding, particularly beneficial for surgeons of varying skill levels. This innovation addresses significant safety concerns during gastric cancer surgery.

Journal Article by Chen G, Xie Y (…) Han F et 5 al. in BJS Open

© The Author(s) 2025. Published by Oxford University Press on behalf of BJS Foundation Ltd.

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GLP-1 Receptor Agonists Show Weight Loss Benefits Post Bariatric Surgery

A systematic review and meta-analysis of 19 studies involving 1,290 patients revealed that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) effectively address suboptimal initial clinical response and weight gain recurrence after bariatric surgery. Notable results included pooled total weight loss percentages of 9.24% for liraglutide, 11.38% for semaglutide, and 15.50% for tirzepatide after three months, alongside significant reductions in various biochemical markers. Adverse events were relatively mild and led to a low discontinuation rate of 3%.

Journal Article by Nie Y, Zhang Y, Liu B and Meng H in Obes Surg

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Transduodenal ampullectomy proves effective for unexplained duct dilation

Transduodenal ampullectomy (TDA) effectively diagnoses and treats unexplained dilation of the cholangiopancreatic duct (UDCD), demonstrating superior diagnostic rates compared to preoperative biopsies (78.41% vs. 65.94%). A study evaluated 203 patients and reported a postoperative complication rate of 27.07% with no mortality. Five-year survival rates varied significantly: 68.31% for adenocarcinoma, 85.99% for adenomas with high-grade dysplasia, and 100% for benign lesions, highlighting TDA’s utility in addressing complex ampullary diseases.

Journal Article by Wang W, Wang J (…) Wang J et 3 al. in Eur J Med Res

© 2024. The Author(s).

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A new nomogram accurately predicts overall survival in rectal cancer.

A novel nomogram has been developed for predicting overall survival (OS) in rectal cancer patients, integrating demographic and clinicopathological data. A prospective cohort study identified significant independent prognostic factors, including Karnofsky Performance Status and TNM stage. The model exhibited a c-index of 0.80 and high predictive accuracy for 1-, 3-, and 5-year OS, outperforming traditional TNM staging. This tool offers healthcare professionals a reliable method to estimate survival outcomes for rectal cancer patients.

Journal Article by Liang L, Li XS (…) Lei HK et 5 al. in World J Gastrointest Oncol

©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.

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New nomogram model accurately predicts survival in gastric cancer patients

A newly developed nomogram model provides effective predictions for overall survival in gastric carcinoma patients. Based on analysis of data from 2018 to 2020, ten independent prognostic factors, including body mass index and TNM stage, were identified. The model demonstrated strong predictive capacity, with AUC values nearing 0.85 for 1-year survival in both training and validation sets. It surpasses traditional TNM staging, aiding clinicians in personalized treatment strategies.

Journal Article by Liang GZ, Li XS (…) Lei HK et 4 al. in World J Gastrointest Oncol

©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.

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Enhanced lymph node dissection improves outcomes in gastric adenocarcinoma patients

Findings indicate that lymph node dissection (LND) during upfront gastrectomy significantly impacts prognostic outcomes for gastric adenocarcinoma (GAC) patients. The study recommends total lymph node (TLN) counts of ≥18 for detecting positive nodes and ≥23 for identifying N3 status. Furthermore, a negative lymph node count (NLN) >9 correlates with better survival in N+ GAC patients, requiring a TLN ≥20 for effective staging. Ultimately, D2 dissection is endorsed as superior for LND effectiveness.

Journal Article by Lee CH, Lee HT (…) Lin CS et 3 al. in Ann Ital Chir

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Video grading predicts bile leak risk in robotic surgeries

Bile leak rates post-robotic pancreatoduodenectomy are substantially reduced when surgical performance is graded. In a multicenter study of 259 patients, an objective structured assessment of technical skills (OSATS) score greater than 21 was linked to a 59.2% relative reduction in bile leaks, with rates decreasing from 12.5% to 5.1%. Additionally, a significant learning curve was identified, with reduced complication rates observed after 19 robotic procedures. These findings support competency-based surgical training to enhance patient safety.

Journal Article by Zwart MJW, van den Broek BLJ (…) Besselink MG et 16 al. in Ann Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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