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Risk Stratification in HCC Patients with VWF-Ag Levels

Von Willebrand Factor Antigen serves as a non-invasive biomarker for clinically significant portal hypertension and predicts time to recurrence and overall survival in hepatocellular carcinoma patients undergoing liver resection. VWF-Ag levels higher than 291% identify a high-risk group with increased posthepatectomy liver failure incidence, while levels of 182% or lower indicate suitability for surgery. VWF-Ag shows similar predictiveness for posthepatectomy liver failure as indocyanine green clearance, offering simplified preoperative risk stratification for resectable HCC patients.

Journal Article by Pereyra D, Mandorfer M (…) Starlinger P et 22 al. in Ann Surg Oncol

© 2024. Society of Surgical Oncology.

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Dietary Adherence Boosts Weight Loss Post-Bariatric Surgery

Adherence to post-surgery dietary recommendations significantly impacts weight loss success after metabolic and bariatric surgery. Factors like pre-surgery BMI, type of surgery, age, physical activity, and depression symptoms also play a role. Adherence peaks within 6 months post-surgery, highlighting the importance of ongoing support and behavior modification interventions for long-term success in managing severe obesity.

Journal Article by Bäuerle A, Marsall M (…) Teufel M et 6 al. in Obes Surg

© 2024. The Author(s).

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Reduction in Hyperuricemia Following Sleeve Gastrectomy

Sleeve gastrectomy surgery led to a significant reduction in hyperuricemia prevalence, improving metabolic syndrome status in patients with obesity. After one year, there was a 46.75% decrease in hyperuricemia cases among females and a 44.44% decrease among males. Enhancements in anthropometric and laboratory measurements were observed, highlighting the clinical relevance of this surgical intervention in managing obesity-related conditions.

Journal Article by Davoudi Z, Shokuhi Sabet A (…) Farsad F et 3 al. in Obes Surg

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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ERAS Guidelines Reduce Hospital Stay and Complications

A meta-analysis of randomized clinical trials found that Enhanced Recovery After Surgery (ERAS) guidelines were associated with decreased hospital length of stay by 1.88 days and reduced risk of complications. However, there was no significant impact on readmission or mortality rates. Future research should focus on improving ERAS implementation and expanding guideline adherence to enhance patient outcomes and surgical recovery.

Meta-Analysis by Sauro KM, Smith C (…) Nelson G et 6 al. in JAMA Netw Open

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Superior Predictive Models for Posthepatectomy Liver Failure

Novel machine learning models demonstrated better performance in predicting clinically significant posthepatectomy liver failure compared to traditional clinical scores, with pre- and postoperative artificial neural network models achieving excellent accuracy. These online interpretable models could serve as valuable decision support tools for identifying high-risk patients before and after surgery, potentially improving outcomes and mortality rates.

Journal Article by Jin Y, Li W (…) Dai X et 7 al. in Int J Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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Identification of Tertiary Lymphoid Structures in Gastric Cancer

Assessment of tertiary lymphoid structures (TLSs) through a digital gene panel proved highly accurate in predicting TLS status and demonstrated associations with survival and response to anti-cancer therapies in gastric cancer patients. Patients with high TLS gene signature exhibited significant benefits from adjuvant chemotherapy and higher response rates to anti-PD-1 immunotherapy. The digital panel offers a reliable alternative for TLS assessment, prognosis, and treatment responses in gastric cancer.

Journal Article by Chen Y, Sun Z (…) Jiang Y et 9 al. in Int J Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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Lymph Node Metastasis Patterns in ESCC Post-Neoadjuvant Therapy

Researchers analyzed 623 esophageal squamous cell carcinoma (ESCC) patients post-neoadjuvant therapy, finding lymph node metastases in 34% of cases. Metastases were most frequent along the right recurrent nerve (10.1%), paracardial station (11.4%), and left gastric artery (10.9%). The data, differentiated by tumor location and pretreatment factors, revealed significant patterns. For instance, metastases were prevalent in the right recurrent nerve (14.2%) for upper thoracic tumors. These findings could refine lymphadenectomy strategies in ESCC surgical management.

Journal Article by Wang CZ, Zhang HL (…) Chen LQ et 6 al. in Dis Esophagus

© The Author(s) 2024. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Osteosarcopenia Predicts Poor Prognosis in Colorectal Cancer Surgery

Osteosarcopenia, identified in 16.5% of patients, significantly increased the risk of postoperative complications after curative surgery for colorectal cancer. Patients with osteosarcopenia had lower 5-year overall survival and recurrence-free survival rates compared to those without osteosarcopenia. Multivariate analysis confirmed osteosarcopenia as an independent prognostic factor for overall and recurrence-free survival. Osteosarcopenia may serve as a valuable predictor for postoperative complications and prognosis in colorectal cancer patients.

Journal Article by Fujimoto T, Tamura K (…) Nakamura M et 9 al. in Surg Today

© 2024. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.

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Use of Shared Decision-Making by Providers in ICU Care for Surgical Patients

Providers in veterans affairs hospitals utilize elements of shared decision-making when caring for critically ill surgical patients in the ICU. Through qualitative interviews, key components of shared decision-making were identified, along with barriers and facilitators to its implementation. These findings offer valuable insights for interventions aiming to enhance shared decision-making in the ICU and other healthcare settings, ultimately improving communication and decision-making processes for surgical patients.

Journal Article by Millis MA, Vitous CA (…) Suwanabol PA et 5 al. in Ann Surg Open

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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Improving Surgical Outcome Data Collection in LMICs

Perioperative data collection is crucial for enhancing surgical safety, yet low- and middle-income countries face significant challenges in this regard. A survey of 229 stakeholders across 36 LMICs revealed common barriers and facilitators to collecting surgical outcome data. Institutions with experience in data collection reported positive impacts on patient care. Mentorship and research training availability were linked to increased publication of surgical outcome data. Targeted interventions can help address these challenges and advance surgical outcome research in LMICs.

Journal Article by Diehl T, Jaraczewski TJ (…) Zafar SN et 9 al. in Ann Surg Open

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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