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Establishment of a patient-specific organoid model for timely pancreatic cancer treatment

Post author By STITCHES Newsletter
Post date 21/06/2024
Categories In General Surgery, HPB & Spleen, Surgical Endoscopy

Patient-derived organoids (PDOs) from EUS-guided biopsies show high success rate in establishing models for pancreatic ductal adenocarcinoma (PDAC). PDAC PDOs accurately reflect genetic alterations in the original tumors and predict drug sensitivity, including resistance to nab-paclitaxel. This innovative model enables rapid testing of multiple therapeutic drugs, offering a personalized “patient avatar” for timely clinical decision-making in PDAC treatment.

Video-Audio Media by Kim H, Jang J (…) Park JK et 16 al. in Gastrointest Endosc

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Polymerase Chain Reaction for Detecting Bacteria in Peritoneal Fluid

Post author By STITCHES Newsletter
Post date 21/06/2024
Categories In Appendix, Gallbladder and Surgical Emergencies, General Surgery

Polymerase chain reaction accurately detects bacteria in peritoneal fluid, guiding postoperative antibiotic treatment in patients with acute appendicitis. Results show concordance of 71.4% between PCR and conventional culture, with Escherichia coli and Bacteroides fragilis being the most common bacteria. Study highlights PCR’s potential in diagnosing bacterial infections, even in cases where conventional culture fails to detect pathogens, emphasizing its utility in clinical management.

Journal Article by Chayed Z, Bro Sørensen D (…) Qvist N et 2 al. in BMC Surg

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Enhanced Gastric Cancer Staging Using New N Classification System

Post author By STITCHES Newsletter
Post date 21/06/2024
Categories In General Surgery, Upper Gastrointestinal Tract

This study developed and validated a new lymph nodal staging system for pt3-4n0-2m0 gastric cancer patients. The new classification, based on examined lymph nodes and lymph node ratio, outperformed the current system in prognostic prediction accuracy. The improved staging method emerged as an independent prognostic indicator, providing enhanced survival analysis for patients. Surgeons are encouraged to consider these factors for better postoperative prognosis assessment.

Journal Article by Yin K, Jin X (…) Yuan L et 10 al. in J Gastrointest Surg

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Beneficial outcomes of total pancreatectomy with islet autotransplantation in genetic pancreatitis

Post author By STITCHES Newsletter
Post date 21/06/2024
Categories In General Surgery, HPB & Spleen

Total pancreatectomy with islet autotransplantation (TPIAT) provides beneficial metabolic and pain relief outcomes in patients with genetic chronic pancreatitis. Patients with genetic etiology undergo TPIAT at a younger age, experience longer symptom duration, and yield lower islet mass, yet maintain similar metabolic function post-transplant. Post-TPIAT, narcotic usage and pain scores significantly decrease, with more genetic patients achieving pain and narcotic freedom. Early consideration of TPIAT in genetic chronic pancreatitis is supported by these findings.

Journal Article by Darden CM, Mohammed ARH (…) Naziruddin B et 7 al. in J Gastrointest Surg

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Subcutaneous Fat Thickness Predicts Postoperative Seroma Risk

Subcutaneous fat thickness (TSF) is linked to higher postoperative seroma risk following laparoscopic hernioplasty. In a study of 229 male patients, factors like longer hernia duration, larger defects, and TSF ≥26.0 mm were associated with increased seroma risk. TSF ≥26.0 mm had an odds ratio of 7.033 for seroma development. TSF could serve as a valuable prognostic factor for seroma post-surgery, enhancing decision-making processes.

Journal Article by Teng S, Xu M (…) Liu Z et 3 al. in Hernia

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Laparo-endoscopic surgery reduces chronic inguinal pain post-hernioplasty

Laparo-endoscopic hernia surgery shows a lower likelihood of chronic inguinal pain compared to lichtenstein repair, with similar recurrence rates. This systematic review and meta-analysis of eight randomized controlled trials involving 1,469 patients provides robust evidence supporting the effectiveness of laparo-endoscopic mesh repair (TAPP and TEP) in reducing chronic pain following inguinal hernia repair procedures.

Journal Article by Lillo-Albert G, Villa EB (…) Pous-Serrano S et 4 al. in Hernia

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Improved Risk Assessment Model for VTE Prophylaxis

The simplified three-factor risk assessment model for venous thromboembolism (VTE) in inguinal hernia patients resulted in higher prophylaxis rates, reduced assessment time, and lower d-dimer levels compared to the Caprini score. Patients identified as high-risk saw significant improvements in prophylaxis. The model did not increase VTE or bleeding risks, demonstrating potential for quick and effective VTE management. Application of this model could enhance postoperative VTE prophylaxis in surgical settings.

Journal Article by Gu ZC, Dai MF (…) Liu YC et 12 al. in Int J Surg

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Thyroglobulin Wash-Out for Lymph Node Metastasis in Thyroid Carcinoma

Post author By STITCHES Newsletter
Post date 21/06/2024
Categories In Endocrine Surgery, General Surgery

Thyroglobulin wash-out after fine-needle aspiration cytodiagnosis effectively evaluates lymph node metastasis in papillary thyroid carcinoma. A cutoff value of 3.2 ng/ml for FNA-TG offers higher accuracy and lower false negatives than single diagnoses. Combining FNAC with FNA-TG increases sensitivity, though specificity decreases slightly. Ultrasonography provides dynamic LN assessment, enhancing diagnostic efficacy without added patient discomfort. Presence of TG in normal lymphocytes near cancer is confirmed, supporting clinical value.

Journal Article by Chen J, Lin Z (…) Zhang X et 2 al. in World J Surg Oncol

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Extended Pharmacologic Prophylaxis Improves Survival in Colon Cancer Patients

Post author By STITCHES Newsletter
Post date 20/06/2024
Categories In General Surgery, Intestine and Lower Gastrointestinal Tract

Extended pharmacologic prophylaxis after colon cancer surgery is associated with improved overall and cancer-specific survival. Results suggest a potential anti-neoplastic effect from heparin derivatives in preventing post-surgical venous thromboembolism. A large database study of 20,102 patients showed significantly higher survival rates in patients who received extended prophylaxis. Multivariable analysis demonstrated a reduced risk of death with prophylaxis, supporting its use for improving outcomes in colon cancer patients.

Journal Article by Booth A, Brinton D (…) Curran T et 6 al. in Ann Surg

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Metabolic Surgery Shows Superior Renoprotective Effects in CKD Patients

Post author By STITCHES Newsletter
Post date 20/06/2024
Categories In General Surgery, Metabolic and Bariatric Surgery

Metabolic surgery significantly reduces kidney impairment progression and lowers the risk of kidney failure or death by 60% and 44%, respectively, when compared to GLP-1 receptor agonists in patients with type 2 diabetes, obesity, and established chronic kidney disease. This highlights the potential of metabolic surgery as a therapeutic option for individuals with CKD and obesity, offering superior renoprotective effects over GLP-1 receptor agonists.

Journal Article by Aminian A, Gasoyan H (…) Rothberg MB et 13 al. in Ann Surg

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