Blog

### Title

Meta-analysis findings show that neoadjuvant imatinib achieves high 1-year, 3-year, and 5-year overall survival rates of 100%, 94%, and 88%, respectively. Patients with gastric and rectal tumors benefit most with an 8-month treatment duration. Additionally, mutational analysis can aid in treatment decision-making. Effective outcomes include an 89% R0 resection rate and a 67% disease response rate, highlighting the potential of neoadjuvant imatinib in locally advanced and metastatic gastrointestinal stromal tumors.

Review by Lam TJR, Udonwa SA (…) Goh BKP et 3 al. in World J Surg

© 2024 International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).

read the whole article in World J Surg

open it in PubMed

MRI Predicts Histological Grades in Soft Tissue Sarcomas

MRI effectively predicts histological grades of soft tissue sarcomas. Peritumoral high-intensity T2-weighted signals and peritumoral postcontrast enhancement are valuable indicators of high-grade tumors. The study’s findings highlight the importance of MRI in treatment decision-making for sarcoma patients, with each score point increment doubling the chance of high-grade tumors.

Journal Article by Marques TMDM, Cerqueira WS (…) Aguiar S et 7 al. in J Surg Oncol

© 2024 Wiley Periodicals LLC.

read the whole article in J Surg Oncol

open it in PubMed

Angioembolization Reduces VTE Risk in Severe Splenic Injuries.

Angioembolization for high-grade splenic injuries leads to significantly lower venous thromboembolism rates compared to splenectomy. Despite less chemoprophylaxis use and delayed initiation, angioembolization is associated with decreased VTE, shorter hospital stays, and lower mortality. Therefore, considering angioembolization as the initial management for stable patients with severe splenic injuries could reduce VTE risk and improve overall outcomes.

Journal Article by Lyons NB, O’Neil CF (…) Meizoso JP et 8 al. in J Surg Res

Copyright © 2024 Elsevier Inc. All rights reserved.

read the whole article in J Surg Res

open it in PubMed

Machine Learning Model for Prediction of Permanent Stoma after Anterior Resection of Rectal Cancer

Retrospective study develops a machine learning model to predict permanent stoma formation post rectal cancer surgery. Utilizing support vector machine algorithm, the model shows high accuracy (AUC: 0.854) in training, testing, and external validation sets, aiding in preoperative patient stratification and personalized treatment plans. Results offer a practical tool for clinicians to enhance patient outcomes and quality of life.

Journal Article by Su Y, Li Y (…) Liu L et 4 al. in Eur J Surg Oncol

© 2024 Elsevier Ltd, BASO ∼ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

read the whole article in Eur J Surg Oncol

open it in PubMed

Disparities in Postoperative Outcomes Among Patients with Inflammatory Bowel Disease

Study reveals black patients with inflammatory bowel disease have higher rates of postoperative infections, morbidity, mortality, and longer hospital stays compared to white or Hispanic patients, despite having fewer comorbidities. This highlights significant racial disparities in postoperative outcomes, emphasizing the need to address social determinants of health to improve equity in care for all patients with inflammatory bowel disease.

Journal Article by Shustak A, Wolfe L (…) Wieghard N et 2 al. in Ann Gastroenterol

Copyright: © Hellenic Society of Gastroenterology.

read the whole article in Ann Gastroenterol

open it in PubMed

Preoperative Very Low-Energy Diets in Obese Patients Undergoing Non-Bariatric Surgery

Patients with obesity undergoing surgery face higher risks, mitigated by preoperative weight loss strategies like very low-energy diets (VLEDs) commonly used in bariatric surgery. However, VLEDs’ application in non-bariatric surgery is understudied. A pilot trial is needed to assess feasibility and safety for a larger trial. The upcoming PREPARE pilot trial will gather crucial data for future definitive studies, potentially transforming preoperative care for obese surgery patients.

Journal Article by McKechnie T, Ramji K (…) Bhandari M et 7 al. in Pilot Feasibility Stud

© 2024. The Author(s).

read the whole article in Pilot Feasibility Stud

open it in PubMed

Increased Risk of Bone Health Issues Following Pancreatic Resection

Patients who undergo pancreatic resection face a 2.4-fold increase in pathological fractures, a 1.4-1.5 fold increase in osteoporosis/osteomalacia, and vitamin-D deficiency. Post-surgery, bone mineral density declines more rapidly compared to historical controls. Older age, pancreatic cancer, and specific surgical procedures contribute to higher rates of bone mineral density loss. Focus on prevention strategies is crucial to reduce the risk of fractures and osteoporosis in these vulnerable patients.

Journal Article by Khalilieh S, Iyer A (…) Nevler A et 7 al. in Ann Surg

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

read the whole article in Ann Surg

open it in PubMed

Antibiotics Post-Pancreaticoduodenectomy Reduce Major Complications

Postoperative antibiotic prophylaxis in pancreaticoduodenectomy bile duct stenting patients significantly reduced major complications such as reoperation and intensive care unit readmission. Targeted antibiotic treatment based on the biliary microbiome decreased the likelihood of developing wound infections. The study emphasizes the importance of appropriate antibiotic prophylaxis in reducing postoperative complications in this patient population.

Journal Article by Steffani M, Jäger C (…) Scheufele F et 4 al. in BMC Surg

Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

read the whole article in BMC Surg

open it in PubMed

Radiotherapy, Diverting Stoma, Anastomotic Leakage, and Anastomotic Distance are Key Predictors for Anastomotic Stricture after Rectal Cancer Surgery

Developed predictive model using a nomogram to predict anastomotic stricture post anterior resection for rectal cancer. Key predictors include radiotherapy, diverting stoma, anastomotic leakage, and anastomotic distance. The model demonstrated high accuracy with AUC of 0.889 for training set and 0.930 for validation set. Nomogram has clinical value in predicting anastomotic stricture, aiding clinicians in improving patient outcomes and quality of life.

Journal Article by Cheng Y, Tian Z (…) Wang D et 5 al. in Surg Endosc

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

read the whole article in Surg Endosc

open it in PubMed

Factors influencing peroral endoscopic myotomy outcomes

Meta-analysis identifies that sigmoid esophagus, type of achalasia, and prior treatments impact the success of peroral endoscopic myotomy (POEM) for achalasia. Specifically, type I and III achalasia, sigmoid esophagus, and past heller myotomy or balloon dilation correlate with higher failure rates. Conversely, type II achalasia shows better response rates. This data can aid in treatment decisions to enhance POEM success in achalasia patients.

Review by Shou Y, Wang X and Liu D in Surg Endosc

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

read the whole article in Surg Endosc

open it in PubMed