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Long-Term Success of Laparoscopic Nissen Fundoplication

Laparoscopic Nissen fundoplication shows strong long-term effectiveness for GERD with high patient satisfaction over 10 years.

  • Heartburn prevalence dropped from 94% to 34% post-surgery.
  • Overall patient satisfaction reached 87%, with 87% willing to repeat the procedure.

Consider LNF for candidates seeking durable symptom relief, keeping in mind potential for gas-bloating and dysphagia in over half of patients.

  • Symptom recurrence occurred in 17%, and reoperation was needed in 6%.

Journal Article by Principe J, Angeramo CA (…) Schlottmann F et 4 al. in Ann Surg

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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Predicting Recurrence in Lymph Node-Negative Pancreatic Tumors

A new risk score for lymph node-negative pancreatic neuroendocrine tumors helps identify patients at risk for recurrence and guides postoperative surveillance.

  • Recurrence rate for lymph node-negative patients was 10.6%, occurring at a median of 32.4 months post-surgery.
  • Risk factors included male sex (2.2x), tumor size ≥3 cm (2.64x), grade 2 or higher (3.70x), and lymphovascular invasion (3.84x).
  • The risk score’s performance was strong, with a c-statistic of 0.83 internally and 0.95 externally, stratifying patients into low (2.4%), moderate (9.0%), and high (27.7%) recurrence groups.

This tool supports tailored long-term surveillance strategies for higher-risk patients after surgery.

Journal Article by Ventin M, Arya S (…) Ferrone CR et 15 al. in JAMA Surg

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Disparities Impact Pancreatic Cancer Outcomes

Multimodal treatment disparities in pancreatic cancer significantly affect patient survival and care.

  • 8,466 patients analyzed; nonmetastatic cases had higher therapy rates than metastatic.
  • Non-Hispanic black patients experienced longer delays to treatment compared to non-Hispanic whites.
  • Uninsured and Medicaid patients showed the highest odds of not receiving therapy in metastatic cases.

Primary resection strongly predicts improved survival outcomes. Addressing these disparities is critical for enhancing patient care strategies.

Journal Article by Galatas A, Malinosky HR (…) Moaven O et 7 al. in J Surg Oncol

© 2025 Wiley Periodicals LLC.

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Predicting Pancreatic Fistula Risk with Elastography

Pre-operative shear wave elastography can effectively predict the risk of post-operative pancreatic fistula (POPF) after partial pancreatectomy, impacting surgical decision-making.

  • In a study of 305 patients, lower elastography measurements correlated with a higher risk of POPF.
  • An integrated prediction model using elastography, BMI, and pancreatic duct dilation accurately assessed POPF risk with AUC values over 0.75.

Utilizing this model could improve patient selection and outcomes in pancreatic surgeries.

Journal Article by Huang J, Chen L (…) Lin M et 5 al. in BMC Gastroenterol

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Conversion Resection Improves Outcomes in Intermediate-Stage HCC

Preoperative conversion therapy significantly enhances surgical outcomes for intermediate-stage hepatocellular carcinoma.

  • 23.2% of patients in the conversion resection group achieved a complete pathological response.
  • Microvascular invasion rates were lower in the conversion group (17.9% vs. 58.6% in direct resection).

Consider conversion therapy to improve pathology and survival before resection in select patients.

  • 51.8% of the conversion resection group showed a major pathological response.

Journal Article by Zhou Y, Wang H (…) Zhang X et 9 al. in Liver Cancer

© 2025 The Author(s). Published by S. Karger AG, Basel.

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Outcomes for Retroperitoneal Sarcoma Patients Improve Significantly

Recent management of primary retroperitoneal sarcomas shows improved survival rates over time.

  • 5-year overall survival increased from 61.7% (2002-2011) to 78.8% (2012-2021).
  • Distant metastases rates decreased in the recent cohort (HR 1.50).

These findings influence patient selection and highlight the need to adopt newer treatment strategies to enhance outcomes.

  • 30-month post-recurrence survival rose dramatically from 41.9% to 65.9%.

Journal Article by Fiore M, Barretta F (…) Gronchi A et 21 al. in Ann Surg Oncol

© 2025. Society of Surgical Oncology.

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AI Enhances Predictions for Oesophagectomy Outcomes

Using explainable AI, we can significantly improve predictions for 90-day mortality and anastomotic leakage after oesophagectomy.

  • The 90-day mortality rate was 6.0%, with anastomotic leakage at 12.4%.
  • Explainable AI achieved an AUC of 0.95 for predicting mortality, compared to 0.88 for traditional methods.

This technology allows for personalized risk assessments, improving decision-making for surgical candidates.

  • Significant predictors included age, ASA class, BMI, and perioperative bleeding, with all factors showing nonlinear relationships.

Journal Article by Djerf S, Åkesson O (…) Frigyesi A et 4 al. in Eur J Surg Oncol

Copyright © 2025. Published by Elsevier Ltd.

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Revisiting Resection Criteria for Hepatocellular Carcinoma

Tumor markers may improve patient selection for liver resection in HCC.

  • In a study of 803 patients, 32.3% of resectable tumors had high tumor markers (AFP > 500 ng/ml or DCP > 1000 mau/ml).
  • TM-high patients had a median survival of 120.7 months, significantly lower than non-TM-high patients at 160.8 months (p = 0.008).

Incorporating tumor markers into resectability criteria could optimize treatment strategies and improve outcomes for patients with HCC.

  • TM-high status was an independent predictor for relapse-free survival and overall survival.

Journal Article by Miura Y, Ashida R (…) Sugiura T et 7 al. in Hepatol Res

© 2025 Japan Society of Hepatology.

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New Prognostic Model for Pancreatic Cancer Outcomes

A novel risk model using stress granule-related gene signatures (sgrgs) shows promise for improving prognostic accuracy in pancreatic ductal adenocarcinoma (PDAC).

  • Four key sgrgs (lama3, itga6, col17a1, top2a) were identified as significant predictors of PDAC prognosis.
  • A nomogram combining age, N stage, and risk score demonstrated strong predictive capacity.

Understanding these markers can enhance patient selection for targeted therapies and improve outcomes in PDAC management.

  • Immune profiling revealed links to M0 macrophages and CD8 T cells, which may inform treatment strategies.

Journal Article by Wang L, Zong L (…) Guan M et 2 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Colorectal Cancer Burden Rising in East Asia: Key Trends and Projections

Colorectal cancer (CRC) incidence and mortality are sharply increasing in East Asia, necessitating targeted surgical interventions and screening.

  • South Korea leads with a 5.29% annual increase in CRC incidence, followed by China at 4.11%.
  • Projections indicate a continued rise in China by 2050, while South Korea’s incidence stabilizes and Japan’s growth slows.

Males, particularly in China and South Korea, show faster incidence increases compared to females, emphasizing the need for gender-specific screening strategies.

  • Aging populations and socioeconomic factors are significant contributors to the rising CRC burden.

Journal Article by Zhang Y, Zhang Y, Lu K and Zhu H in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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