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Impact of Pancreatic Duct Topography on Surgical Outcomes in Pancreatic Cancer

Findings from a study on 105 patients who underwent Whipple’s procedure for pancreatic cancer revealed that inferior pancreatic duct topography was linked to higher rates of metastatic spread and tumor recurrence, as well as reduced overall and recurrence-free survival. Conversely, posterior pancreatic duct topography was associated with lower incidence of perineural sheet infiltration and improved overall survival. These results highlight the importance of considering pancreatic duct anatomy in surgical planning to tailor personalized approaches and improve patient outcomes.

Journal Article by Harris MC, Atanasov G (…) Kanhere H et 6 al. in ANZ J Surg

© 2024 Royal Australasian College of Surgeons.

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Isolated Hepatic Perfusion with Melphalan in Uveal Melanoma Liver Metastases: Survival and Health-related Quality of Life Results

Survival and quality of life outcomes in patients with uveal melanoma liver metastases treated with isolated hepatic perfusion were evaluated in a Phase III randomized controlled trial. Isolated hepatic perfusion led to significantly longer progression-free survival compared to standard care, but no significant difference in overall survival at 24 months. Patients receiving isolated hepatic perfusion also experienced better health-related quality of life outcomes over 12 months post-treatment.

Journal Article by Olofsson Bagge R, Nelson A (…) Lindnér P et 15 al. in Ann Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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Active Surveillance for Complete Responders in Oesophageal SCC: Better Progression-Free Survival

Patients with oesophageal squamous cell carcinoma who underwent active surveillance after chemoradiotherapy showed comparable overall survival but better progression-free survival than those who had planned surgery. The two groups had similar overall recurrence rates, with locoregional recurrence more common in the active surveillance group and systemic recurrence more common in the surgery group. Active surveillance was found to be feasible and safe for patients with complete response after chemoradiotherapy.

Journal Article by De Pasqual CA, Weindelmayer J (…) Giacopuzzi S et 6 al. in Br J Surg

© The Author(s) 2024. Published by Oxford University Press on behalf of BJS Foundation Ltd. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Impact of Behavioral Health Disorders on Surgical Outcomes and Survival of Cancer Patients

Patients with behavioral health disorders (BHD) had lower rates of resection and higher odds of complications, longer hospital stays, readmission, and higher in-hospital expenditures. They were also less likely to achieve a postoperative textbook outcome and had worse long-term survival. Initiatives targeting BHD are crucial to improve surgical outcomes and prognosis in cancer patients.

Journal Article by Katayama ES, Woldesenbet S (…) Pawlik TM et 7 al. in J Am Coll Surg

Copyright © 2024 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Does Laparoscopic Gastric Ischemic Preconditioning Reduce Anastomotic Stricture Rate After Esophagectomy?

According to the study, laparoscopic gastric ischemic preconditioning (LGIP) may decrease the rate and severity of anastomotic strictures following esophagectomy. Of the patients who underwent LGIP, only 7.1% developed anastomotic strictures compared to 19.9% in the control group. While controlling for confounders, the difference was no longer significant. There was also a trend towards less severe strictures and decreased need for endoscopic dilation in the LGIP group.

Journal Article by Stuart CM, Mott NM (…) Meguid RA et 9 al. in Ann Surg Oncol

© 2024. Society of Surgical Oncology.

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Low Colorectal Cancer Risk After Resection of High-Risk Pedunculated Polyps

CRC incidence is significantly higher in patients with high-risk adenomas (HRAs) diagnosed at colonoscopy, with a 1.53-fold increase in risk. However, patients with only distal pedunculated polyps without high-grade dysplasia do not have an increased CRC risk. The presence of certain risk factors explains most of the excess CRC risk in the HRA group, indicating potential reduced burden of surveillance in FIT programs.

Journal Article by Zorzi M, Battagello J (…) Hassan C et 24 al. in Clin Gastroenterol Hepatol

Copyright © 2024 AGA Institute. Published by Elsevier Inc. All rights reserved.

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Improvement in Clinical Outcomes and Diagnostic Accuracy with Multidisciplinary Management of Retroperitoneal Liposarcoma

Multidisciplinary team management in retroperitoneal liposarcoma treatment led to higher overall survival rates at 1, 3, and 5 years, improved diagnostic consistency, reduced perioperative mortality and postoperative complications, and enhanced disease awareness and postoperative compliance. The intervention showed significant benefits in clinical outcomes and diagnostic accuracy, highlighting the importance of multidisciplinary approaches in managing retroperitoneal liposarcoma patients undergoing surgery.

Journal Article by Fan P, Tao P (…) Tong H et 7 al. in BMC Surg

Copyright © 2024 Elsevier Inc. All rights reserved.

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What are the distinct quality-of-life trajectories after pelvic exenteration?

Quality of life trajectories after pelvic exenteration diverge into distinct classes, with most patients experiencing optimal outcomes. Two classes were identified for physical scores and three for mental and functional scores, with higher overall survival probabilities in the optimal trajectory class. Age, repeat surgery, neoadjuvant therapy, surgical margin, operation duration, and hospital stay were significant predictors of quality-of-life classes.

Journal Article by Steffens D, Blake J (…) Koh CE et 5 al. in Dis Colon Rectum

Copyright © The ASCRS 2024.

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Reduced Postoperative Laboratory Testing Improves Outcome After Colorectal Surgery

After implementing a reduction in postoperative laboratory testing following colorectal surgery, the intervention group experienced a 33% decrease in tests per hospital stay, a 26% decrease per day, and a 49% increase in test-free days, with no impact on length of stay or readmissions. The nonintervention group did not show significant changes in laboratory work. These findings highlight safe and significant reductions in postoperative laboratory work, promoting high-value surgical care.

Journal Article by Dave YA, Temple LKF (…) Cannon LM et 4 al. in Dis Colon Rectum

Copyright © The ASCRS 2023.

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Intraoperative Leak Testing Reduces Anastomotic Leakage in Gastric Cancer Surgery

Intraoperative leak testing (IOLT) significantly reduced postoperative anastomotic leakage (PAL) incidence compared to no intraoperative leak testing (NIOLT) in gastric cancer surgery. IOLT was associated with lower rates of anastomotic-related complications and reoperations. These findings suggest that IOLT is a promising tool to improve postoperative outcomes in gastric cancer surgery, emphasizing the need for further investigation before potential inclusion in future clinical guidelines.

Review by Luo H, Liu S (…) Tian Y et 7 al. in Surg Endosc

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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