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Platelet Count Ratio Predicts Long-Term Survival in Left Pancreatectomy for PDAC

After left pancreatectomy for pancreatic adenocarcinoma, patients with a perioperative platelet count ratio (PPR) ≥ 1.5 had significantly longer median overall survival (OS) compared to those with PPR < 1.5 (40 months vs. 20 months). PPR was identified as a biomarker for predicting long-term survival in these patients, suggesting its potential as a prognostic factor in PDAC cases following left pancreatectomy.

Journal Article by Nachmany I, Gudmundsdottir H (…) Pencovich N et 8 al. in J Clin Med

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Same-Day Discharge Trends in Bariatric Surgery

Same-day discharge (SDD) after bariatric operation has increased from 2.4% in 2016 to 7.4% in 2021. The study found that black/African American race, history of myocardial infarction, renal insufficiency, DVT, and smoking were preoperative factors associated with increased complications for SDD. SDD for RYGB had a 72% increased risk of postoperative complications compared with SG. While major complications were lower in the SDD cohort, there was a significant increase in deaths, cardiac arrest, and dehydration requiring treatment compared with admission.

Journal Article by Bharani T, Tavakkoli A (…) Sheu EG et 2 al. in J Am Coll Surg

Copyright © 2024 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Remission of Obesity-Related Sleep Apnea After Metabolic and Bariatric Surgery Reduces Mortality and Cardiovascular Events

After metabolic and bariatric surgery, 74% of patients achieved remission of obesity-related sleep apnea, which was associated with significantly lower risks of overall mortality and major cardiovascular events compared to those who did not reach remission. The risk for death and cardiovascular events in the remission group was similar to a control group without sleep apnea at baseline. Regular follow-up for patients not achieving remission is crucial.

Journal Article by Stenberg E, Ottosson J and Näslund E in J Am Coll Surg

Copyright © 2024 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Validation of a Laparotomy Simulation Model for Surgical Training

Researchers assessed a simulated laparotomy incision and closure-training model using a quantitative study design. The model was found to be realistic and useful as a teaching tool, with strong content validity evidence. Experts outperformed novices in the evaluation. Pre and post-test assessments showed a significant increase in confidence levels, providing strong validity evidence for the novel simulation-training model.

Journal Article by Roche AF, Kavanagh D (…) Condron CM et 6 al. in Am J Surg

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

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Optimal Extent of Lymph Node Dissection for High-Risk Gastric Cancer

High-risk gastric cancer patients may benefit from limited lymph node dissection (LND), while standard LND improves relapse-free survival in low-risk patients. Limited LND reduces postoperative complications in low-risk patients, without affecting outcomes in high-risk patients. Pancreatic fistula was not observed in the limited dissection group, suggesting it may be the optimal treatment for high surgical risk gastric cancer patients.

Journal Article by Kuroda K, Miki Y (…) Maeda K et 7 al. in World J Surg

© 2024 International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).

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Role of Intestinal Microbiota in Modulating Antitumor Effects of Oncolytic Virus Vaccines in Colorectal Cancer

Intestinal microbiota composition plays a crucial role in modulating the antitumor effects of oncolytic virus vaccines (OVVs) in colorectal cancer (CRC). OVVs significantly inhibit tumor growth and prolong survival in early-stage CRC but have minimal impact in advanced stages. Probiotics and fecal microbiota transplantation enhance OVVs’ effectiveness in advanced CRC by increasing activated CD8 T cell abundance. These findings highlight the potential of manipulating intestinal microbiota to improve the efficacy of OVVs in treating CRC.

Journal Article by Chen X, Wang G (…) Li J et 2 al. in Dig Dis Sci

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Refusal of Surgery in Rectal Cancer: Shortened Survival Despite Some Achieving Complete Clinical Response

Rectal cancer patients who refused surgery despite incomplete response to neoadjuvant therapy had shortened overall survival (OS). Some patients converted to a complete clinical response (CCR) on subsequent staging, leading to prolonged OS. Patients with near CCR at initial endoscopic staging may benefit from prolonged monitoring before declaring CCR. Increased physician visits and testing were observed in patients who opted for a watch-and-wait approach or refused total mesorectal excision.

Journal Article by Labadie KP, Olson KA (…) Melstrom KA et 7 al. in J Surg Oncol

© 2024 Wiley Periodicals LLC.

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Impact of Right Hepatic Artery Anomalies on Pancreatoduodenectomy Outcomes

In periampullary cancer patients undergoing pancreatoduodenectomy, anomalies in the right hepatic artery (RHA) anatomy, including accessory or replaced RHAs, were observed in 16.3% of cases. However, when comparing outcomes with a propensity score-matched analysis, the presence of these anomalies did not significantly impact perioperative complications or histopathological findings. High-volume centers performing pancreatoduodenectomy can manage cases with anomalous RHA without a notable increase in adverse outcomes.

Journal Article by De Sio D, Lucinato C (…) Alfieri S et 11 al. in Langenbecks Arch Surg

© 2024. The Author(s).

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Impact of Hand Dominance on Laparoscopic Surgical Skills

Researchers found significant differences in skill acquisition and proficiency between dominant and non-dominant hands in laparoscopic surgical training. Network models and EMG data analysis effectively captured muscle activity and learning progression, suggesting the need for tailored training approaches. NASA-TLX scores correlated with performance, emphasizing the importance of objective and subjective measures in training. Personalized protocols based on hand dominance could enhance surgical precision, efficiency, and patient outcomes, revolutionizing surgical education and improving patient care.

Journal Article by Malisetty S, Rastegari E, Siu KC and Ali HH in J Clin Med

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Increased Risk of Delirium after Non-Cardiac Surgery Linked to Preoperative Glucose Dysregulation

Preoperative glucose dysregulation, including hyperglycemia, hypoglycemia, or both, was associated with a higher incidence of delirium within 30 days after non-cardiac surgery. The hazard ratios for the development of delirium were increased in patients with hyperglycemia, hypoglycemia, and both types of dysregulation. Interestingly, hyperglycemia was consistently associated with postoperative delirium in all patients, regardless of diabetes status. These findings highlight the importance of monitoring glucose levels for preventing delirium after surgery.

Journal Article by Oh AR, Lee DY (…) Park J et 4 al. in J Clin Med

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