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AI’s Pivotal Role in Accelerating Clinical Trials and Medical Breakthroughs

Revolutionizing clinical trials, AI enables expedited and streamlined processes through automated data generation and management. It interprets data, facilitates biosimulation and early disease diagnosis, and reduces costs and time while improving efficiency and drug development research. The study highlights how AI revolutionizes data collection methods and overcomes challenges in clinical trials, emphasizing its noteworthy implications for accelerating medical research.

Journal Article by Chopra H, Annu None (…) Emran TB et 4 al. in Int J Surg

Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

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Comparable Long-Term Survival in Robot-assisted and Laparoscopic Surgery for Colon Cancer

The study aimed to compare long-term survival outcomes in patients undergoing robot-assisted surgery (RAS) or laparoscopic surgery (LAS) for colon cancer. The analysis included 7565 patients, out of which 6905 (91%) underwent LAS and 660 (9%) underwent RAS. The findings revealed that LAS patients had a significantly higher risk of cancer recurrence compared to RAS patients. However, there were no significant differences between the two surgical platforms in terms of all-cause mortality or colon cancer-specific mortality.

Journal Article by Cuk P, Kaalby L (…) Ellebæk MB et 2 al. in Ann Surg

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Addressing Social Determinants of Health Improves Surgical Patients’ Quality of Life

A retrospective analysis of 8,512 surgical patients revealed that 25.2% reported at least one social determinant of health (SDOH) need. Factors such as food insecurity, housing instability, lack of transportation, and unmet medication needs were identified as independent predictors of poor physical and mental health. The study emphasizes the importance of assessing and addressing SDOH needs in healthcare settings and by policymakers to improve health-related quality of life among surgical patients.

Journal Article by Malapati SH, Edelen MO (…) Pusic AL et 8 al. in Ann Surg

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No Significant Benefit of Goal-Directed Albumin in High-Risk Surgeries

In this randomized clinical trial, researchers investigated whether goal-directed albumin substitution could reduce postoperative complications in high-risk surgery patients. They found that maintaining a serum albumin concentration >30 g/l perioperatively did not significantly reduce the incidence of postoperative complications compared to standard care.

Journal Article by Schaller SJ, Fuest K (…) Jungwirth B et 9 al. in Ann Surg

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High incidence of psychological distress before and after major elective noncardiac surgery

One-third of adults experience moderate to severe psychological distress before major elective noncardiac surgery, with 32.6% reporting distress before surgery. This distress tends to persist or worsen over time, with 27.3% experiencing distress at 30 days after surgery and 26.2% at 1 year after surgery. Females and patients undergoing orthopedic procedures show slight improvement, while males and patients undergoing nonorthopedic procedures do not. Younger age, poor self-reported functional capacity, smoking history, and undergoing open surgery are predictors of severe and/or worsened psychological distress.

Journal Article by Gandotra S, Daza JF (…) Wijeysundera DN et 3 al. in Ann Surg

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Defining a Framework and Checklist for Sustainable Global Surgical Partnerships

A study aimed to establish a concrete and realistic framework with evaluation metrics to assess sustainability in global surgical partnerships (GSPs) through a modified Delphi technique. Consensus was achieved among 50 global surgery experts from 34 countries, resulting in the development of a 47-item checklist for the evaluation of the six pillars of sustainability in GSPs. This consensus-driven framework provides the first tool for building sustainable GSPs and promoting noncolonial solutions to improving access to quality surgical care in low-resource settings.

Journal Article by Binda CJ, Adams J (…) Joos E et 5 al. in Ann Surg

Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

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An Optimized Follow-Up Strategy for Esophageal Cancer Patients: Personalized and Cost-Effective Surveillance Protocols

Researchers conducted a cohort study involving 4688 patients with esophageal cancer to develop an optimized postsurgery follow-up strategy. By using recursive partition analysis and a random survival forest, patients were stratified into four groups based on pathological features, with surveillance strategies developed for each group. These strategies were validated and found to outperform mainstream guidelines in terms of cost-effectiveness and efficiency. The study also supported the use of specific imaging techniques for high-risk groups. Overall, this study provides evidence for personalized and economical follow-up strategies and offers insights for optimizing follow-up in other cancer types.

Journal Article by Mai Z, Xie J (…) Fu J et 5 al. in Int J Surg

Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

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Comparing the Incidence of Bile Reflux and Quality of Life Among Different Reconstruction Methods After Laparoscopic Distal Gastrectomy

The study aimed to compare the incidence of bile reflux, quality of life (QOL), and nutritional status among different reconstruction methods after laparoscopic distal gastrectomy. The results showed that Roux-en-Y reconstruction had the lowest incidence of bile reflux, followed by Billroth II with Braun anastomosis, and then Billroth II. Billroth II with Braun anastomosis was better than Billroth II in terms of anti-reflux capability and QOL. However, it did not perform as well as Roux-en-Y in preventing bile reflux and reducing postoperative nausea symptoms. Nutritional status and morbidities were similar among the three groups.

Journal Article by Park SH, Hur H (…) Park S et 18 al. in Int J Surg

Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

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R Anastomosis is a Safe and Effective Technique for B-II-B Anastomosis During Laparoscopic Gastrectomy

R Anastomosis, a novel technique for B-II-B anastomosis during laparoscopic distal gastrectomy, was compared to conventional anastomosis in a propensity score matching analysis. The study included 246 patients, with 123 in each group. The R group had significantly reduced anastomotic time, and there were no intraoperative complications, conversions to open surgery, or perioperative mortalities reported in either group. Furthermore, the R technique demonstrated potential in reducing postoperative gastric emptying dysfunction. These findings suggest that R Anastomosis is a safe and effective technique for B-II-B anastomosis during laparoscopic gastrectomy.

Journal Article by Zhou J, Zhang Q (…) Wang D et 4 al. in Int J Surg

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Efficiency of Retraction Method in Esophagectomy for Squamous Cell Carcinoma

A prospective randomized trial compared two methods of lymphadenectomy along the left recurrent laryngeal nerve (lrln) during minimally invasive esophagectomy in esophageal squamous cell carcinoma patients. The retraction method (rm) was found to be more beneficial, as it reduced surgical duration significantly compared to the suspension method (sm). There were no differences in postoperative complications, disease-free survival, overall survival, or quality of life between the two methods.

Journal Article by Wang YJ, He XD (…) Guo W et 4 al. in Int J Surg

Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

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