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Correlation between primary and secondary cancers

Many cancer survivors are at risk of developing a second primary cancer (SPC), which affects their prognosis. This study conducted a systematic review and meta-analysis of 9 million cancer patients to explore correlations between SPCs and first primary cancers (FPCs). The analysis revealed specific associations between certain FPCs and the development of SPCs in different organs. For example, patients with gynecological or thyroid cancer had a higher likelihood of developing breast or colorectal cancer as an SPC. These findings emphasize the importance of close clinical follow-up and monitoring for early diagnosis and better screening of SPCs in patients with relevant FPCs.

Journal Article by Wang X, Zeng M (…) Luo P et 9 al. in Br J Surg

© The Author(s) 2023. Published by Oxford University Press on behalf of BJS Society Ltd. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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High Incidence of Pancreatic Exocrine Insufficiency After Non-Pancreatic Upper Gastrointestinal Surgery: Implications for Enzyme Replacement Therapy

Approximately 36% of patients who undergo non-pancreatic upper gastrointestinal surgeries develop pancreatic exocrine insufficiency (PEI), which can have detrimental effects on their health. The incidence of PEI was found to be 23% after bariatric metabolic surgery and 50.4% after oesophagogastric resection, with even higher rates after certain procedures. Diagnostic testing using fecal elastase 1 was commonly utilized, and enzyme replacement therapy, when prescribed, showed positive results in 78.6% of patients. Therefore, clinicians should be vigilant in recognizing and treating PEI following non-pancreatic upper gastrointestinal surgery.

Journal Article by Hall LA, Powell-Brett S (…) Roberts KJ et 4 al. in Br J Surg

© The Author(s) 2023. Published by Oxford University Press on behalf of BJS Society Ltd. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
© The Author(s) 2023. Published by Oxford University Press on behalf of BJS Society Ltd. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Management and Prognosis of Gastric Neuroendocrine Tumors

Gastric neuroendocrine tumors (G-NETs) are rare tumors originating from the gastric mucosa, classified into three subtypes based on their characteristics and behavior. Type 1 and 2 are typically multifocal and associated with elevated serum gastrin levels. Type 2 causes symptoms like abdominal pain and diarrhea. Type 3, sporadic and solitary, has the most aggressive phenotype. Treatment and prognosis vary based on tumor type, size, and stage, with type 1 having the best prognosis and type 3 having the worst. A comprehensive review discusses the presentation, workup, and surgical management of G-NETs.

Review by Sok C, Ajay PS (…) Shah MM et 2 al. in Ann Surg Oncol

© 2023. Society of Surgical Oncology.

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A Unique Surgical Technique for Type III Portal Annular Pancreas using Hanging Maneuver and ICG Fluorescence Imaging

Robotic Pancreatoduodenectomy in a patient with Type III Portal Annular Pancreas (PAP) was successfully performed using the hanging maneuver and indocyanine green (ICG) fluorescence imaging. The technique involved transecting the pancreas into the neck of the anteportal portion and stapling the retroportal portion after dissection and encircling with hanging tape. ICG fluorescence imaging confirmed the blood supply from mesenteric vessels. The study highlights the importance of surgical strategy based on the fusion and ductal anatomy of the pancreas in PAP cases.

Journal Article by Takagi K, Fuji T (…) Fujiwara T et 4 al. in Ann Surg Oncol

© 2023. Society of Surgical Oncology.

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Frailty, Not Age, Determines Adverse Outcomes in Minimally Invasive Adrenalectomy Surgery

The study evaluated the impact of frailty on complications and length of stay after minimally invasive adrenalectomy surgery. It found that frailty, rather than age, was a better predictor of adverse outcomes. The study included 8,693 patients who underwent the surgery, and the results showed low 30-day mortality and complication rates. Frailty was associated with higher rates of complications, while age did not have a significant impact.

Journal Article by Ahuja V, Gibson C, Machado N and King JT in BMC Surg

Published by Elsevier Inc.

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Long-Term Quality of Life: Laparoscopic vs. Open Pancreatoduodenectomy

Three randomized controlled trials have reported improved functional recovery after laparoscopic pancreatoduodenectomy (LPD) compared to open pancreatoduodenectomy (OPD). This monocentric retrospective cross-sectional study found that patients who underwent LPD had significantly higher quality of life scores, better pancreas specific health status, improved physical functioning, and fewer limitations in activities compared to patients who underwent OPD. Additionally, LPD patients reported better scar scores in terms of esthetics, satisfaction, and reduced chronic pain. These results suggest that LPD may be a preferable surgical approach for patients with benign and premalignant diseases.

Journal Article by Dagorno C, Marique L (…) Dokmak S et 11 al. in Surg Endosc

© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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High-resolution 3D CT Aids in Hiatal Hernia Diagnosis and Surgical Planning

The study demonstrates that high-resolution 3D computed tomography (CT) is a valuable tool for assessing the anatomical characteristics of hiatal hernias (HH) and aiding in surgical planning for laparoscopic or robotic antireflux procedures. CT scans accurately identified HH in 70% of patients and correlated well with endoscopic findings. Furthermore, the distance between the esophagogastric junction and the hiatus was found to significantly correlate with the area of the esophageal hiatus. However, no correlation was observed between CT and manometric findings or the Demester score.

Journal Article by Santana AV, Herbella FAM (…) Patti MG et 6 al. in Surg Endosc

© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Laparoscopic Surgery for Adrenocortical Carcinoma: Identifying Risk Factors for Noncurative Resection

In recent years, there has been an increased use of minimally invasive surgery (MIS) for adrenocortical carcinoma (ACC). However, MIS has been associated with noncurative resection and locoregional recurrence. This study aimed to identify risk factors for margin-positive resection in ACC patients undergoing MIS. Factors such as increasing age, nonacademic center, advanced tumor stage, and right-sided tumors were associated with noncurative resection. A predictive model incorporating these factors was able to stratify patients at risk. These findings can improve patient selection and minimize the risk of noncurative surgery.

Journal Article by Carlisle K, Blackburn KW (…) Hu Y et 6 al. in J Surg Oncol

© 2023 Wiley Periodicals LLC.

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Increase in demand for surgical procedures for cancer care in low- and middle-income countries

Over 5 billion people worldwide lack access to basic surgical procedures, and it is projected that the number of surgical procedures needed for cancer care will rise by 5 million between 2018 and 2040. The greatest surge in demand is expected in low- and middle-income countries. The article highlights the progress made in surgical cancer care globally, including political support and workforce advancements, while also addressing gaps that still need to be addressed, such as the impact of the COVID-19 pandemic and the significance of high value cancer care.

Review by Murthy SS and Are C in J Surg Oncol

© 2023 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC.

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Older Adults Experience Significant Impact on Their Quality of Life and Psychosocial Well-being Following Major Elective Surgery

Older adults undergoing major elective surgery experience significant impact on their valued life activities and psychosocial well-being due to postoperative symptoms, according to a qualitative study. Participants felt unprepared for the intensity and duration of these symptoms and expressed a need for additional support and education on symptom management. The most frequently mentioned symptoms included postoperative pain, gastrointestinal discomfort, anxiety/stress, and depression. Assessing patient-reported symptom burden postoperatively and implementing interventions to minimize it in older adults can optimize their recovery and overall quality of life.

Journal Article by Keny C, Dillon EC (…) Tang V et 3 al. in Ann Surg

Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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