A study comparing high-grade solid pseudopapillary neoplasms (hg-SPNs) with conventional SPNs (c-SPNs) found that hg-SPNs exhibit more aggressive malignant characteristics, such as larger tumor size, true necrosis, high-grade nuclear atypia, and lymphatic and/or venous invasion. All hg-SPN patients died of the disease, while c-SPN patients were alive without recurrence. Genetic analysis showed ctnnb1 mutations in […]

In a comprehensive multidisciplinary clinic, molecular profiling of intrahepatic cholangiocarcinoma (ICC) identified actionable molecular alterations in 45% of patients, including mutations and amplifications. Among 120 patients with molecular profiling, the detection of these alterations significantly improved mean overall survival (OS) by 10.5 months. Additionally, in 70 patients with non-metastatic ICC, the detection of actionable molecular […]

South Korean patients with Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) showed significant variations in adherence to treatment guidelines over the study period of 2008-2016. Adherence to guidelines, particularly those recommended by the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases […]

Perioperative hypothermia is not significantly correlated with surgical site infections (SSI) in patients undergoing liver resection, according to a retrospective cohort study. Researchers analyzed data from 4,000 patients and found that among those with hypothermia, 6.8% developed SSI. However, after propensity score matching, there were no substantial differences in SSI rates between the hypothermia and […]

Iterative revisions of risk-stratified pancreatectomy clinical pathways were associated with a 32% decrease in 90-day perioperative costs. The study included 814 patients with three iterations of the pathways, and each iteration showed a decrease in accordion grade 3+ complications and median hospital stays without an increase in readmissions. The greatest savings were seen in the […]

This study compared the impact of subclassifying intrahepatic cholangiocarcinoma (ICC) into small and large duct types, on the selection of appropriate surgical strategies. By analyzing 118 patients who underwent liver resection, researchers found that patients with small duct-type ICC had better outcomes with hepatectomy alone, while those with large duct-type ICC benefited from advanced procedures […]

Non-autologous reinforcement of the pancreatic stump following distal pancreatectomy significantly reduces the rate of postoperative pancreatic fistula (POPF), according to a meta-analysis of nine randomized clinical trials. The pooled analysis found a lower rate of POPF in the non-autologous reinforcement group compared to the non-reinforcement group. Heterogeneity was observed in the 95% predictive interval, but […]

Despite improvements in survival over the years, pancreatic cancer continues to have poor outcomes compared to other malignancies. Multimodal treatment approaches involving chemotherapy, surgery, and radiotherapy have been studied extensively. Emphasis is now placed on selecting appropriate treatments based on local extension into major vessels. Recent advancements in treatment regimens offer new strategies for managing […]

A new study investigated the prognostic value of perioperative lymphopenia on short- and long-term outcomes in patients undergoing resection of hepatocellular carcinoma (HCC). Researchers found that perioperative lymphopenia, particularly severe lymphopenia on postoperative day 5, was associated with worse 5-year overall survival and disease-free survival. Patients with severe lymphopenia also had a higher incidence of […]

Ondansetron, a serotonin receptor antagonist, shows promise as a safe and effective treatment for patients with Low Anterior Resection Syndrome (LARS). In a randomized study, patients who received ondansetron experienced a significant decrease in LARS severity and improvement in symptom scores compared to those who received a placebo. The study suggests that ondansetron can improve […]