Newsletter
Best Papers in General Surgery
The five that matter, every day.
A study established two nomograms to predict risks and prognosis for T1-T2 stage gastric cancer patients with lymph node metastasis. Analyzing data from 5,350 patients, key risk factors included age, tumor size, and grade. The developed nomograms demonstrated excellent calibration and clinical applicability, significantly distinguishing…
A novel therapeutic approach utilizing a sustained-release anti-JUN agent demonstrated significant efficacy in preventing postoperative adhesions in preclinical models. Encapsulated in a shear-thinning hydrogel, this small-molecule inhibitor minimized adhesion quantity and reduced fibrosis at the microstructural level. The treatment proved safe and well-tolerated in both…
A novel machine learning model successfully predicts postpancreatectomy acute pancreatitis (PPAP) in patients following pancreaticoduodenectomy. In a cohort of 381 patients, 88 (23.09%) developed PPAP, which was notably associated with a higher occurrence of postoperative pancreatic fistulas (55.68%). Various algorithms, including logistic regression and gradient…
Elevated preoperative levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and cancer antigen 125 (CA125) in colorectal cancer patients with peritoneal metastases significantly influence overall survival. In a study of 204 patients, the presence of high CA19-9 and CA125 was linked to poorer outcomes,…
A comparative study of autologous flap-supported loop stomas revealed significant benefits over traditional rod-supported loop stomas. The intervention group showed lower short-term complication rates, particularly in peristomal dermatitis and stoma leakage, alongside reduced stoma appliance replacement frequency and costs. Additionally, operating times and blood loss…
Identifying 26 unique perioperative pathways in emergency laparotomy, the review highlights a significant variability in interventions among 44,055 patients. Most studies were at moderate risk of bias, and 66.6% failed to report TIDIER framework items, indicating inadequate reporting practices. Outcomes measured primarily focused on morbidity,…
A novel predictive and prognostic signature, named chemoresist, was developed to assess the outcomes of patients with pancreatic ductal adenocarcinoma (PDAC) post-surgery and adjuvant chemotherapy. In a multicohort analysis, significant survival differences were noted between high and low chemoresist patients, with median overall survival reaching…
A systematic review and meta-analysis involving 15,817 patients revealed that avoiding routine abdominal drainage following left pancreatectomy significantly reduces major morbidity, postoperative pancreatic fistula rates, readmissions, and surgical site infections. The no-drain group experienced a 23% reduction in major complications and substantially lower rates of…
An evidence-based enhanced recovery after surgery (ERAS) protocol has significantly improved outcomes for older adults undergoing gastrointestinal surgery. In a trial involving 392 patients, those receiving the new nursing model exhibited lower heart rates, stable blood parameters, and reduced postoperative complications compared to a control…
A prospective cohort study involving 66 patients with ultra-low rectal cancer revealed that colonic j-pouch reconstruction significantly enhances bowel function and quality of life compared to direct anastomosis. At all postoperative intervals (1, 3, and 6 months), patients who received the j-pouch exhibited superior LARS…
