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Endoscopic Submucosal Dissection Offers Hope for GERD-Related Neoplasms

Endoscopic submucosal dissection (ESD) proves highly effective in treating GERD-related neoplasms, achieving a 100% en bloc resection rate and a 95.8% curative resection rate among 96 patients. Remarkably, no local recurrences or metastases were observed during follow-ups. After six months, nearly 70% of patients experienced alleviated GERD symptoms, linked to the extent of resected lumen circumference. Major complications were observed in only 8.4% of cases, underscoring ESD’s safety and efficacy.

Journal Article by Chen Z, Leng Z (…) Xu M et 7 al. in Surg Laparosc Endosc Percutan Tech

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Laparoscopic Repeat Liver Resection Outperforms Open Surgery in Key Metrics

Laparoscopic repeat liver resection (LRLR) significantly reduces intraoperative blood loss, complications, and hospital stays compared to open repeat liver resection (ORLR) for recurrent liver cancer. LRLR boasts a higher R0 resection rate, making it a safer, more effective option for patients. While operative time, transfusion rates, mortality, and three-year survival show no significant differences between techniques, the advantages of LRLR position it as a compelling choice in clinical practice.

Review by Ding Z, Yu T, Fang H and Wang Z in Updates Surg

© 2025. Italian Society of Surgery (SIC).

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New Metric Establishes Clinical Relevance of Surgical Complications in Abdominal Surgery

A novel minimal important difference (MID) for the Comprehensive Complication Index (CCI) offers clarity on surgical outcomes for major abdominal surgery patients. Analyzing data from 1,583 patients across four studies, findings reveal an MID of 12 points in the CCI crucial for interpreting clinical significance and guiding sample size calculations in future research. This metric emphasizes patient-centered outcomes, bridging gaps between statistical significance and meaningful clinical changes.

Journal Article by Abbassi F, Pfister M (…) Clavien PA et 18 al. in Ann Surg

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Radical Resection Outperforms Preservation in Congenital Bile Duct Surgery

In a comprehensive multicenter trial involving 355 patients with type I congenital bile duct dilation, radical extrahepatic cyst excision, compared to subtotal excision, markedly improved long-term outcomes. The radical approach significantly reduced rates of recurrent cholangitis, pancreatitis, and readmission, leading to better quality of life metrics and lower carcinogenesis risk. Both techniques showed similar perioperative complications, establishing radical resection as the superior choice for patients with intrapancreatic bile duct involvement.

Journal Article by Yang CZ, Zhu CZ (…) Dong JH et 24 al. in Ann Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Immune Checkpoint Inhibitors Triple Pathological Response in Locally Advanced Rectal Cancer

Neoadjuvant immune checkpoint inhibitors boost pathological complete response rates in locally advanced rectal cancer, ranging from 25-62.5%. The clinical complete response rates also soared—hitting 100% in some cases of dMMR/MSI-H tumors. Sphincter preservation rates reached up to 100%. Despite promising outcomes, the evidence stems from a limited number of phase I/II trials without long-term survival data, highlighting the need for robust studies to verify these gains.

Journal Article by Mui M, Kong JC (…) Heriot AG et 3 al. in Dis Colon Rectum

Copyright © The ASCRS 2025.

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Landmark Study Maps Esophageal Cancer Survival Rates by Stage and Treatment

A comprehensive analysis of 7,855 esophageal cancer cases in Denmark reveals crucial survival outcomes based on treatment strategies. Definitive chemoradiotherapy offers lower overall survival compared to surgery, yet outperforms palliative care. Interestingly, stage IVB patients undergoing surgery showed unexpectedly favorable survival. This research leverages the Union for International Cancer Control staging system to refine prognostic accuracy, aiming to enhance individualized treatment protocols and clinical decision-making in esophageal cancer management.

Journal Article by Kempf ON, Thorsen LBJ (…) Achiam M et 8 al. in Dis Esophagus

© The Author(s) 2025. Published by Oxford University Press on behalf of the International Society for Diseases of the Esophagus. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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Low Skeletal Muscle Gauge Elevates Mortality Risk After Emergency Laparotomy

Low skeletal muscle gauge (SMG) significantly predicts higher 30-day and 90-day mortality following emergency laparotomy, with odds ratios of 2.12 and 2.64, respectively. Patients presenting with acute abdominal pain should undergo routine computed tomography reporting of body composition, as low SMG also correlates with prolonged hospital stays. With a study cohort of 1,090 patients, this analysis underscores the necessity of incorporating body composition assessments into risk prediction models for surgical outcomes.

Journal Article by Evans RPT, Raveshia D (…) Tan BHL et 4 al. in BJS Open

© The Author(s) 2025. Published by Oxford University Press on behalf of BJS Foundation Ltd.

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Nurse-guided program boosts quality of life for LARS patients post-surgery

A patient-centered program targeting low anterior resection syndrome (LARS) significantly enhances postoperative quality of life. In a multicenter trial, participants who engaged with the LARS patient-centered program reported a mean global quality of life of 79.7, compared to 67.8 in standard care, six months after surgery. This improvement continued at the 12-month mark. Additionally, the program reduced the incidence of major LARS complications one month post-surgery, underscoring the effectiveness of guided self-management.

Multicenter Study by Garfinkle R, Demian M (…) Boutros M et 15 al. in Ann Surg

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Early VTE Prophylaxis Cuts Risk of Complications in Major Trauma Patients

Initiating pharmacologic venous thromboembolism (VTE) prophylaxis within 24 hours of major trauma admission dramatically lowers VTE risk by 42%, according to a large cohort study. Among 6,569 patients, those receiving early treatment experienced significantly fewer VTE events (2.8% compared to 7.8%) and showed reduced mortality rates (0.6% vs. 1.8%). Crucially, early initiation did not increase the risk of bleeding complications, supporting a shift towards this practice as standard care.

Journal Article by Kerwin AJ, Byerly S (…) Knudson MM et 4 al. in Ann Surg

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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Novel Technique Cuts Chylous Fistula Rates in Thyroid Surgery

A new surgical method—reverse-sequence dissection—dramatically reduces chylous fistula occurrences after lateral neck lymph node dissection for thyroid cancer. In a study of 989 patients, those undergoing the novel technique showed a chylous fistula rate of just 0.81%, compared to 5.05% in the traditional method cohort. This advancement not only enhances surgical safety but also offers a promising avenue for further refining thyroid cancer operations.

Journal Article by Liu L, Liu H (…) Yu D et 4 al. in Am Surg

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