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A novel MRI-based model predicts perineural invasion in cholangiocarcinoma

An innovative MRI-based fusion model effectively predicts perineural invasion (PNI) status in intrahepatic cholangiocarcinoma (ICC) patients. The model, incorporating deep learning, radiomics, and clinical features, was developed from a study involving 192 patients. In the training phase, it achieved an AUC of 0.905 and 82.3% accuracy, while the external test set yielded an AUC of 0.760 and 77.8% accuracy. These results indicate its potential to enhance preoperative staging and guide adjuvant therapy decisions.

Journal Article by Qi Z, Yuan H (…) Li D et 7 al. in World J Surg Oncol

© 2025. The Author(s).

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Tumor volume and reduction predict colorectal liver metastases outcomes

Evaluation of total metastases volume (TMV) and relative volume reduction (RVR) reveals their superior predictive ability over established clinical risk scores (CRS) for colorectal liver metastases post-neoadjuvant chemotherapy. Patients with TMV below 29.5 ml before and 7.5 ml after therapy had significantly longer progression-free survival (PFS) and overall survival (OS). An RVR of at least 73% also demonstrated considerable positive impact on both PFS and OS compared to lower reductions.

Journal Article by Lindenlaub F, Asenbaum U (…) Kaczirek K et 4 al. in Ann Surg Oncol

© 2025. The Author(s).

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Endoscopic ultrasound predicts outcomes in esophageal cancer treatment

A predictive model utilizing endoscopic ultrasound (EUS) parameters has been developed, demonstrating significant efficacy in predicting pathologic complete response (PCR) in esophageal cancer patients undergoing neoadjuvant immunotherapy combined with chemotherapy. Key predictors identified were treatment regimen, negative biopsy findings, RECIST assessment, EUS responsiveness, and downstaging. The model showed an area under the curve of 0.840 and was validated internally. EUS responder status also emerged as a crucial predictor of overall survival.

Journal Article by Liu QN, Chen YF, Luo GY and Zhang X in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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ω-3 Fish Oil Emulsion Reduces Delayed Gastric Emptying Risk

In patients undergoing Roux-en-Y reconstruction for gastric cancer, ω-3 fish oil fat emulsion significantly decreased the incidence of delayed gastric emptying (DGE) from 15.5% to 4.3%, highlighting its protective role. The intervention group also experienced a shorter median hospital stay of 10 days compared to 13 days for controls. Multivariate analysis further solidified ω-3 supplementation as an independent protective factor against DGE, supporting its integration into enhanced recovery protocols for surgical patients.

Journal Article by Jing S, Chen H (…) Wang M et 6 al. in J Gastrointest Surg

Copyright © 2025. Published by Elsevier Inc.

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Patients with alcohol-related cirrhosis face significantly higher surgery rates

A nationwide study in Denmark reveals that patients with alcohol-related cirrhosis have a substantially elevated risk of requiring surgery compared to matched individuals from the general population. With a 1-year surgery risk of 42.6% for these patients, versus 13.4% for comparators, the incidence rate ratio for surgeries overall stood at 3.38. Notably, abdominal procedures were most common, indicating a pressing need for improved perioperative management in this high-risk group.

Journal Article by Birn-Rydder R, Herting EC (…) Jepsen P et 3 al. in Scand J Gastroenterol

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Key risk factors for readmission after colorectal cancer surgery identified

A meta-analysis revealed a 11.73% rate of unplanned readmissions within 31 days post-colorectal cancer surgery. Significant risk factors include age, postoperative complications, advanced tumor stage, rectal tumor site, stoma creation, complicated diabetes, Charlson comorbidity index, blood transfusions, longer hospital stays, and surgical approach. Additionally, being female emerged as a protective factor. The findings emphasize the need for targeted interventions to mitigate these risks and enhance patient outcomes, supporting healthcare professionals in their logistical planning.

Systematic Review by Qu N, Li T (…) Cui L et 2 al. in BMC Gastroenterol

© 2025. The Author(s).

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Indeterminate bile duct cytology carries significant malignancy risks

A systematic review revealed that among 8,458 bile duct samples with indeterminate cytology, the overall risk of malignancy was 60.1%. Specifically, atypical cytology had a malignancy risk of 50.4%, while suspicious cytology exhibited a higher risk at 80.2%. Furthermore, suspicious cytology significantly correlated with a 1.59-fold increased risk of malignancy compared to atypical results. These findings underscore the importance of accurate preoperative risk assessment in patients with biliary strictures.

Journal Article by Lieb KR, Williams ZE (…) Dhir M et 2 al. in Ann Surg Oncol

© 2025. Society of Surgical Oncology.

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Laparoscopic approach reduces postoperative fluid collections and recovery time.

Ultrasonography proved vital in assessing postoperative fluid collections after pancreaticoduodenectomy. A study of 309 patients revealed that those undergoing laparoscopic pancreaticoduodenectomy (LPD) experienced significantly fewer fluid collections (39.2% vs. 59.3%) and shorter hospital stays (16 vs. 21 days). Additionally, LPD patients had reduced fever duration, faster catheterization, fewer required tubes, and shorter extubation times. These findings highlight the effectiveness of laparoscopic techniques in improving postoperative outcomes.

Journal Article by Zhang L, Zhang S (…) Zhang D et 7 al. in Eur J Med Res

© 2025. The Author(s).

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Proton beam therapy effectively manages hepatocellular carcinoma

Through a comprehensive review, researchers highlight the efficacy of proton beam therapy (PBT) in managing hepatocellular carcinoma (HCC), particularly for patients with portal vein tumor thrombosis (PVTT). PBT demonstrates promising tumor local control and overall survival rates while offering a safer alternative to traditional photon radiotherapy. It effectively downstages HCC for liver transplantation, proving non-inferior to various non-surgical treatments. Future studies should explore PBT combinations with other therapeutic modalities for enhanced outcomes.

Review by Chok KS, Joeng TY and Poon DM in Expert Rev Gastroenterol Hepatol

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Remote patient monitoring significantly improves wound care outcomes

A systematic review of 51 studies revealed that remote patient monitoring (RPM) is highly effective for wound care, with 93.75% of the analyzed studies showing positive results. The review, covering research from 2008 to 2023, emphasizes the role of RPM in enhancing healthcare quality and decreasing unnecessary hospital visits through efficient online communication between physicians and patients. Future investigations should focus on optimizing RPM strategies for continued advancements in wound care in Pakistan.

Systematic Review by Tanveer F, Sajwani K (…) Zehra UUB et 2 al. in J Pak Med Assoc

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