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Comparing Liver Transplant and Liver Resection for Multifocal Hepatocellular Carcinoma

Liver transplant (LT) was associated with improved long-term survival compared to liver resection (LR) in patients with multifocal hepatocellular carcinoma (MHCC). Factors such as race, insurance status, and treatment facility influenced the likelihood of receiving LT. This study highlights the clinical and sociodemographic disparities between LT and LR patients, emphasizing the lower mortality risk associated with LT. However, the study’s results are limited by the selection criteria for MHCC within Milan criteria.

Journal Article by Kakish H, Suraju MO (…) Aziz H et 5 al. in J Gastrointest Surg

Copyright © 2024 Society for Surgery of the Alimentary Tract. Published by Elsevier Inc. All rights reserved.

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Analysis of Learning Curve in Robotic Hepatectomies

Analysis of 500 robotic hepatectomies revealed significant number of cases needed to achieve mastery in minor, major, and technically challenging resections. Surgeons can utilize this data to enhance patient safety and outcomes, providing valuable insights for those gaining experience in robotic hepatectomies. The findings highlight the importance of overcoming specific learning curves to achieve long-term proficiency in hepatobiliary robotic surgery.

Journal Article by Dugan MM, Christodoulou M (…) Sucandy I et 3 al. in J Gastrointest Surg

Copyright © 2024 Society for Surgery of the Alimentary Tract. Published by Elsevier Inc. All rights reserved.

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Improved Recurrence Surveillance with Personalized Circulating Tumor DNA Monitoring

Personalized circulating tumor DNA monitoring using a tumor-informed assay significantly improves recurrence surveillance and management in patients with colorectal liver metastases. Detectable ctDNA at specific time points post-surgery is associated with higher recurrence risk, serving as an independent prognostic marker. Longitudinal ctDNA analysis accurately predicts relapse, leading to increased secondary resection rates and improved outcomes.

Journal Article by Li Y, Xu J (…) Peng J et 16 al. in Int J Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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Comparing Oxycodone and Sufentanil for Postoperative Pain Management

Patients undergoing laparoscopic gallbladder-preserving cholecystolithotomy were divided into oxycodone and sufentanil groups. Oxycodone group showed lower pain scores postoperatively, indicating better analgesic effects and reduced inflammatory responses compared to sufentanil group. This prospective randomized controlled trial highlights the superior postoperative analgesia induced by oxycodone in this patient population, as well as its potential to minimize inflammatory reactions.

Journal Article by Wang Y, Wu M (…) Zhao L et 2 al. in Front Surg

© 2024 Wang, Wu, Zhao, Yan and Zhao.

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Impact of Resection Margin on Survival in Colorectal Liver Metastasis

Resection margin width significantly influences overall survival post liver resection for colorectal liver metastasis. A cohort study of 754 patients revealed poorer survival with margins of 0-0.9mm compared to ≥1mm, even in the era of modern chemotherapy. Narrow margins (<1mm) associated with a 1.4-fold higher risk of mortality. A ≥1mm margin is crucial for optimal outcomes in patients with colorectal liver metastasis.

Research Support, Non-U.S. Gov’t by Östrand E, Rystedt J (…) Buchwald P et 6 al. in BJS Open

© The Author(s) 2024. Published by Oxford University Press on behalf of BJS Foundation Ltd.

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Comparison of D2 lymphadenectomy vs. D2 lymphadenectomy + complete mesogastric excision in gastric cancer

Adding complete mesogastric excision to D2 lymphadenectomy for gastric cancer improves 3-year disease-free survival without significant difference in overall survival rates. Recurrence rates were lower in the complete mesogastric excision group. This finding suggests potential benefits of the combined approach for better outcomes in advanced gastric cancer patients.

Comparative Study by Xie D, Shen J (…) Gong J et 11 al. in Br J Surg

© The Author(s) 2024. Published by Oxford University Press on behalf of BJS Foundation Ltd. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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Arterial Divestment Techniques for Locally Advanced Pancreatic Cancer

Utilizing periarterial and sub-adventitial divestment alongside the triangle operation and RAMPS, researchers achieved R0 resection in locally advanced pancreatic body cancer without compromising oncologic outcomes. The technique, demonstrated in a multimedia article, provides an alternative to morbid arterial resection, ensuring optimal tumor clearance and preserving patient outcomes.

Journal Article by Kumar NAN, Palod A, Usman N and Ahmed S in Ann Surg Oncol

© 2024. The Author(s).

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Enhancing HIPEC Efficacy with Bromelain in Appendiceal Cancer

Bromelain enhances cytotoxicity and mucolytic activity in appendiceal cancer tumors, reducing mucin production and increasing drug effectiveness in heated intraperitoneal chemotherapy (HIPEC) treatments. Combined with N-acetylcysteine, bromelain significantly reduces mucin levels and boosts cell death pathways like apoptosis and autophagy. These findings suggest a promising role for bromelain as a potent pretreatment agent in augmenting HIPEC outcomes for appendiceal cancer patients.

Journal Article by Wajih N, Erali RA (…) Votanopoulos KI et 6 al. in Ann Surg Oncol

© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.

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Effectiveness of Paragastric Neural Blockade for Pain, Nausea, and Vomiting Control Post-Sleeve Gastrectomy

Paragastric neural blockade (PGNB) significantly reduces postoperative pain and nausea/vomiting after sleeve gastrectomy, as evidenced by lower visual analog scale (VAS) and postoperative nausea and vomiting (PONV) scores. Additionally, PGNB facilitates earlier mobilization and higher patient satisfaction compared to the control group, indicating its efficacy and safety in managing early postoperative symptoms in patients undergoing laparoscopic sleeve gastrectomy.

Journal Article by Katar MK and Turan UF in Obes Surg

© 2024. The Author(s).

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Comparing Liver Transplant and Resection for Multifocal Hepatocellular Carcinoma

Study compares long-term outcomes of liver transplant (LT) and resection (LR) in patients with multifocal hepatocellular carcinoma (MHCC). LT associated with improved survival over LR, with LT patients more likely to be non-Hispanic white, privately insured, and treated at academic centers. Findings suggest LT may be the preferable surgical option for MHCC, with implications for clinical decision-making.

Journal Article by Kakish H, Suraju MO (…) Aziz H et 5 al. in J Gastrointest Surg

Copyright © 2024. Published by Elsevier Inc.

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