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Best Papers in General Surgery
The five that matter, every day.
A patient-centered program targeting low anterior resection syndrome (LARS) significantly enhances postoperative quality of life. In a multicenter trial, participants who engaged with the LARS patient-centered program reported a mean global quality of life of 79.7, compared to 67.8 in standard care, six months after…
Initiating pharmacologic venous thromboembolism (VTE) prophylaxis within 24 hours of major trauma admission dramatically lowers VTE risk by 42%, according to a large cohort study. Among 6,569 patients, those receiving early treatment experienced significantly fewer VTE events (2.8% compared to 7.8%) and showed reduced mortality…
A new surgical method—reverse-sequence dissection—dramatically reduces chylous fistula occurrences after lateral neck lymph node dissection for thyroid cancer. In a study of 989 patients, those undergoing the novel technique showed a chylous fistula rate of just 0.81%, compared to 5.05% in the traditional method cohort.…
In a comprehensive analysis of over 26,000 patients, fully covered self-expandable metal stents (FCSEMS) with endoscopic retrograde cholangiopancreatography (ERCP) emerged as the safest preoperative biliary drainage method, boasting fewer adverse events than plastic stents. However, they showed a higher incidence of pancreatitis. Plastic stents are…
GNAS droplet digital PCR effectively enhances the diagnosis of mucinous pancreatic cystic neoplasms (MPCNs) in fine-needle aspiration samples. In a cohort of 140 patients, this method achieved a 62% detection rate for MPCNs and identified 33% of inconclusive lesions as MPCNs, all with 100% specificity.…
Why knowing when not to place a drain may matter more than how to manage one.
Artificial intelligence now enhances surgical trial design by generating synthetic data that mirrors real-world outcomes with high fidelity. In evaluating transanal transection and single-stapled anastomosis, the AI approach yielded a balanced cohort of 1,200 patients, verifying a significantly lower anastomotic leak rate in the new…
Hypothetical interventions targeting nutrition, anxiety, and family cohesion significantly lower frailty risk among older gastric cancer patients. A single focus on nutrition proved most effective, reducing risk by 21%. Joint interventions yielded even greater results, with all-factor combinations slashing risk by over 31%. These findings…
Transcutaneous electrical acupoint stimulation (TEAS) significantly accelerates gastrointestinal recovery after abdominal surgery, according to a meta-analysis of 16 randomized controlled trials involving 2,300 patients. TEAS decreases time to first flatus and defecation, expedites oral intake, and reduces postoperative nausea and vomiting. It also lessens pain…
Postoperative anti-PD-1 therapy significantly enhances overall survival and recurrence-free survival in hepatocellular carcinoma (HCC) patients, particularly those with vessels encapsulating tumor clusters (VETC), a marker of aggressive disease. Among 388 patients studied, those receiving the therapy showed improved outcomes compared to untreated counterparts, while VETC…
