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Clinical Impact of Combined Tumour-Infiltrating Lymphocytes and Microsatellite Instability Status in Colorectal Cancer

Tumour-infiltrating lymphocytes (TIL) and microsatellite instability (MSI) status are key prognostic factors in colorectal cancer. A meta-analysis of 14,028 patients revealed that TIL-high (TIL-H) subtype correlated with improved overall survival. The integrated MSI-TIL classification shows promise as a predictive tool for clinical decisions in early-stage colorectal cancer. Further exploration is warranted for its potential clinical utility.

Journal Article by Wankhede D, Yuan T (…) Hoffmeister M et 3 al. in Lancet Gastroenterol Hepatol

Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.

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Effectiveness of Reinforcement in Laparoscopic Sleeve Gastrectomy

Stapler line reinforcement with continuous imbricating sutures in laparoscopic sleeve gastrectomy significantly reduces leakage rates and reoperation rates postoperatively. A retrospective study involving 510 patients revealed a lower leakage incidence (0.7% vs. 4%) in the reinforcement group compared to the non-reinforcement group. While staple line bleeding did not differ, the reinforcement technique showcased improved outcomes with minimal complications.

Journal Article by Coşkun M, Uprak TK (…) Cingi A et 2 al. in Surg Laparosc Endosc Percutan Tech

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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Prognostic Value of Combined Tumor Markers in Colon Cancer Patients

Study investigates the combined tumor markers CEA and CA19-9 in colon cancer patients. 531 patients underwent curative resection, with higher preoperative and postoperative tumor marker levels associated with lower recurrence-free and overall survival rates. Patients with elevated postoperative tumor markers had increased risk of recurrence and death. Normalization of markers post-surgery improved prognosis. Postoperative tumor markers better predicted outcomes than preoperative markers.

Journal Article by Pan HF, Zheng ZF (…) Chi P et 3 al. in Surg Laparosc Endosc Percutan Tech

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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Perineural Invasion in Stage I-III Colon Cancer: Prognostic and Predictive Significance

Perineural invasion is an independent poor prognostic factor in stage III colon cancer but does not predict outcomes in node-negative disease. Adjuvant chemotherapy benefits patients with node-positive but not those with node-negative disease when perineural invasion is present. Higher recurrence odds are seen only in poorly differentiated tumors among perineural invasion-positive tumors. Findings discourage adjuvant chemotherapy use in node-negative colon cancer with perineural invasion due to potential adverse effects.

Journal Article by Chu CH, Lai IL (…) You JF et 5 al. in World J Surg Oncol

© 2024. The Author(s).

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Risk Factors for Delayed Gastric Emptying after Laparoscopic Pancreaticoduodenectomy

Delayed gastric emptying (DGE) after laparoscopic pancreaticoduodenectomy (LPD) was studied in 827 patients. Preoperative biliary drainage, blood loss, and major complications were significant risk factors for DGE. Higher BMI, soft pancreatic texture, and perioperative transfusion increased the risk of secondary DGE. Identifying at-risk patients can lead to early interventions and improved clinical decisions for shorter perioperative management durations.

Journal Article by Meng L, Li J (…) Peng B et 4 al. in BMC Surg

© 2024. The Author(s).

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Impact of 3D-Printed Models on Complications in Hepatobiliary Laparoscopic Surgery

3D-printed models reduce intraoperative blood loss and postoperative complications, particularly bile leakage, in complex hepatobiliary laparoscopic surgeries. Patients guided by 3D models had significantly lower comprehensive complication index scores compared to the control group. Multivariable analysis confirmed 3D models as independent protective factors against complications. Subgroup analysis emphasized the efficacy of 3D models in reducing complications, especially in patients with intrahepatic cholelithiasis.

Journal Article by Yao WF, Huang XK (…) Huang DS et 10 al. in BMC Surg

© 2024. The Author(s).

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Development of a Mortality Risk Calculator for Interhospital Transfer of Unseen General Surgery Patients

Development of a risk calculator using 12 variables showed excellent predictive ability for mortality among unseen emergency general surgery patients at the time of interhospital transfer. With a mortality rate of 6.0%, the model demonstrated high performance metrics with an area under the receiver operating characteristic curve of 0.851, sensitivity of 0.90, specificity of 0.67, and balanced accuracy of 0.79. This tool could aid in patient triage, resource allocation, and standardizing care.

Journal Article by Al-Deen Said S, Gentle CK (…) Augustin T et 7 al. in Ann Surg

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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Impact of County-Level Provider Density on Colorectal Cancer Mortality

High county-level provider density is linked to lower colorectal cancer-related mortality rates, independent of social vulnerability index. Efforts to increase access to health care providers could enhance health care equity and long-term cancer outcomes. Low provider density areas exhibited higher crude mortality rates compared to moderate or high provider density areas. This study underscores the crucial role of health care providers in reducing colorectal cancer mortality on a population level.

Journal Article by Khan MMM, Munir MM (…) Pawlik TM et 8 al. in BMC Surg

Copyright © 2024 Elsevier Inc. All rights reserved.

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Symptom Resolution and Survival Benefits of Palliative Surgery in Advanced Cancer

In a single-center experience, 127 patients underwent palliative surgery for advanced cancer, with a high symptom resolution rate of 89%. Complication and mortality rates were 19.7% and 6%, respectively. Successful symptom palliation significantly correlated with the potential to resume systemic chemotherapy, impacting overall survival. Palliative surgery showed effectiveness in symptom relief and survival enhancement, especially when enabling further anticancer treatment. Prospective data collection is recommended to ensure optimal patient care.

Journal Article by Maddalon B, Cenzi C (…) Sommariva A et 12 al. in Eur J Surg Oncol

© 2024 Published by Elsevier Ltd.

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Comparative Analysis of Liver Resection for Non-B Non-C and Virus-Associated Hepatocellular Carcinoma

Increasing cases of non-hepatitis B and non-hepatitis C hepatocellular carcinoma (NBNC-HCC) prompt a comparison with hepatitis virus-associated HCC. A retrospective study of 1321 liver resections showed comparable operative outcomes and long-term survival between matched NBNC-HCC and HV-HCC groups. Independent prognostic factors for overall survival were identified, with NBNC-HCC cases reaching up to 70% of total resections.

Journal Article by Takamoto T, Nara S (…) Shimada K et 4 al. in Eur J Surg Oncol

© 2024 Elsevier Ltd, BASO ∼ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

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