In the realm of esophageal squamous cell carcinoma (ESCC), the battle between neoadjuvant chemotherapy (NAC) and adjuvant chemotherapy (AC) takes center stage. A squad of 684 ESCC patients engaged in this retrospective face-off at Henan Cancer Hospital. Post Propensity Score Matching (PSM), the NAC squad flexed its muscles, showcasing prolonged overall survival (OS) and disease-free […]
Category: Upper Gastrointestinal Tract
Comparing Laparoscopic and Open Approaches for Peptic Ulcer Perforation
This study scrutinizes laparoscopic versus open surgery for peptic ulcer perforation (PUP). Analyzing 29 studies (17,228 patients), laparoscopy emerges as a superior choice. Laparoscopic intervention correlates with shorter hospital stays, reduced blood loss, and fewer complications. Remarkably, laparoscopy also exhibits a lower mortality rate. However, it’s not without its complexities, showing a higher overall complication […]
CRP: Early Indicator of Anastomotic Leakage After Esophageal Cancer Surgery
In the world of esophageal cancer surgery, a study from Karolinska University Hospital unveils CRP (C-reactive protein) as a superhero. Analyzing 612 patients, the research identifies a spike of ≥4.65% in CRP levels between postoperative days 2 to 3 as a signal for anastomotic leakage (AL) risk after esophagectomy. Those with CRP over 211 mg/L […]
Navigating Neoadjuvant Therapies for Esophageal Cancer
In the exploration of treatments for advanced esophageal squamous cell carcinoma (ESCC), researchers compared outcomes of neoadjuvant chemotherapy (NCT), neoadjuvant chemoradiotherapy (NCRT), and neoadjuvant immunochemotherapy (NICT). NCRT and NICT groups exhibited superior pathological responses, with higher pathologic complete response rates (29.9% and 23.6%, respectively) compared to NCT (8.1%). NCRT significantly reduced lymph node metastasis in […]
Intraperitoneal Paclitaxel Shows Promise: Effective and Tolerable Combo for Gastric Cancer with Peritoneal Metastasis
In a phase II study, researchers explored the efficacy of intraperitoneal paclitaxel combined with S-1 and cisplatin for gastric cancer with peritoneal metastasis. Among 53 patients, the treatment achieved a 73.6% 1-year overall survival rate, meeting the primary endpoint. The median survival time was 19.4 months, and the 1-year progression-free survival rate reached 49.6%. While […]
Insights from Percutaneous Transesophageal Gastro-Tubing in Japan
In a comprehensive study of 3,684 patients undergoing percutaneous transesophageal gastro-tubing (PTEG) in Japan, researchers found a mere 1.3% complication rate. PTEG served diverse purposes, with 1,455 cases for decompression and 2,193 for feeding. Notably, complications led to minimal invasive treatments, predominantly red blood cell transfusions and tube replacements. This real-world analysis not only sheds […]
Unmasking Esophageal Cancer: V’ and U’ Variables Shine Bright
Researchers unveil a tech-savvy twist to esophageal cancer diagnosis, sidelining the subjective pink-color sign’s (PCS) hiccups. Testing the V’ variable solo, results hit 73.91% sensitivity, lagging behind human eyes. But, combining V’ and U’ variables steps up the game, matching seasoned endoscopists with 86.30% accuracy. The modified V’ + U’ method proves a reliable diagnostic ally, hinting […]
Gastric Cancer: Prognostic Impact of Categorized Tumor Deposits
In a gastric cancer retrospective study, researchers classified tumor deposits into distinct types. Of 868 patients, 11.1% had tumor deposits, revealing poorer survival (3-year overall survival: 53.2%) compared to those without (87.0%). Irregular nodule and the tumor deposits complex showed the worst prognosis (3-year overall survival: 41.9%), while smooth nodule displayed a better outcome (3-year […]
Robotic Triumph: US Study Reveals Advantages in Gastric Cancer Surgery
In the quest for optimal gastric cancer surgery, a study of 11,173 patients in the US compared robotic and laparoscopic gastrectomy. The analysis revealed that robotic gastrectomy (RG) outshone laparoscopic gastrectomy (LG) in terms of adequate lymphadenectomy, negative margins, shorter hospital stay, lower mortality, and superior 5-year overall survival. Propensity score matching affirmed RG’s superiority […]
Missed Opportunities: Esophageal Adenocarcinoma Patients with Prior Colonoscopies Lack Timely Esophagogastroduodenoscopy
In the era of widespread colonoscopy, many patients later diagnosed with esophageal adenocarcinoma (EA) had prior screening colonoscopies, presenting missed opportunities for earlier detection. Among 221 referred patients, 49% had prior colonoscopies, yet only 18% had an esophagogastroduodenoscopy (EGD) before EA diagnosis. Most displayed gastroesophageal reflux disease symptoms or acid medication use during screening colonoscopy. […]