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Sex Differences in Weight Loss and Complications Post Bariatric Surgery

Male patients had slightly greater weight loss and higher complication rates compared to females following bariatric surgery. However, these differences were not clinically significant. Providers should consider referring males earlier for surgery given their higher comorbidity rates. This study highlights the need to assess sex differences in outcomes to personalize bariatric care effectively.

Journal Article by Hider AM, Bonham A (…) Ehlers AP et 4 al. in J Surg Res

Copyright © 2024 Elsevier Inc. All rights reserved.

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Filgotinib 200 mg Shows Efficacy in Perianal Fistulising Crohn’s Disease

Filgotinib 200 mg demonstrated efficacy in treating perianal fistulising Crohn’s disease, with a higher proportion of participants achieving a combined fistula response compared to lower doses and placebo. Serious adverse events were more frequent with the 200 mg dose, but no treatment-related serious adverse events or deaths were reported. Filgotinib 200 mg was generally well tolerated, showing promise as a potential treatment option for this condition.

Multicenter Study by Reinisch W, Colombel JF (…) Gecse KB et 7 al. in J Crohns Colitis

© The Author(s) 2024. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation.

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High Rates of Colitis-Associated Post-Colonoscopy Colorectal Cancers

Analysis reveals 61% of inflammatory bowel disease-related colorectal cancers were post-colonoscopy, often due to delays in surveillance and missed lesions in areas of inflammation. Proactive strategies are needed to reduce endoscopic burden and improve surveillance adherence, as traditional methods show limitations in detecting aggressive cancer evolution. Molecular biomarkers may enhance risk assessment in future clinical practice.

Multicenter Study by Kabir M, Thomas-Gibson S (…) Wilson A et 11 al. in J Crohns Colitis

© The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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Development of Gallstone Recurrence Prediction Model

A nomogram model was developed to predict gallstone recurrence after gallbladder-preserving surgery based on identified risk factors. Factors such as gallstone duration, symptoms, number of stones, cholecystitis history, and diet were significant predictors. The nomogram showed good predictive value (c-index = 0.692). Clinicians can utilize this model to strategize treatment for gallstone patients, suggesting caution with gallbladder-preserving surgery for those at high recurrence risk.

Journal Article by Liu P, Chen YW (…) Xia NX et 5 al. in Hepatobiliary Pancreat Dis Int

Copyright © 2022 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.

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Improved Surgical Outcomes with Thoracic Duct Visualization

Patent blue injection enhances intraoperative thoracic duct visualization during esophagectomy. In a pilot trial, the duct was visualized in 60% of patients, leading to significantly shorter operative times, fewer complications, and shorter hospital stays compared to controls. Although chyle leak rates did not significantly differ, this simple method shows promise for improving surgical outcomes in minimally invasive esophagectomy.

Journal Article by Berger Y, Bard V (…) Kashtan H et 3 al. in Eur Surg Res

© 2024 The Author(s). Published by S. Karger AG, Basel.

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Optimal Proximal Margin Length Improves Prognosis in Adenocarcinoma of Gastroesophageal Junction

Study finds proximal margin length ≥1.2 cm linked to improved outcomes in Siewert II/III adenocarcinoma of esophagogastric junction, lowering risk of disease progression. This offers valuable guidance for surgical decision-making and enhances patient outcomes, particularly for subgroups with specific tumor characteristics. These findings emphasize the importance of optimal proximal margin length in surgical approaches for adenocarcinoma of the gastroesophageal junction.

Journal Article by Pang T, Nie MM (…) Yin K et 4 al. in Asian J Surg

Copyright © 2024 Asian Surgical Association and Taiwan Society of Coloproctology. Published by Elsevier B.V. All rights reserved.

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Improved Survival Prediction in Intrahepatic Cholangiocarcinoma

Preoperative CT radiomics of intrahepatic cholangiocarcinoma and peritumoral tissue enhances survival prediction. Combined with clinical data, the radiomic model achieves equivalent prognostic estimates compared to postoperative pathology. In a study of 215 patients, the addition of radiomic features led to a significant improvement in overall and progression-free survival predictions. Consideration of both portal and arterial phases is crucial for accurate prognostication.

Journal Article by Fiz F, Rossi N (…) Viganò L et 26 al. in Ann Surg Oncol

© 2024. Society of Surgical Oncology.

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Combination Therapy Improves Survival in Early-Onset Pancreatic Cancer

Study on non-metastatic early-onset pancreatic cancer patients showed postoperative survival improvement with adjuvant therapy. Surgery followed by neoadjuvant and adjuvant therapy recommended for locally advanced cases. 1-year, 2-year, and 3-year overall survival rates were 84.3%, 51.5%, and 27.6% respectively. Findings suggest a positive impact of combination therapy including surgery, radiotherapy, and chemotherapy on survival outcomes in non-metastatic early-onset pancreatic cancer patients.

Journal Article by Zhang LT, Zhang Y (…) Wang J et 2 al. in World J Gastroenterol

©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

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Anti-reflux mucosectomy reduces reflux symptoms in GERD patients

Anti-reflux mucosectomy (ARMS) effectively reduced reflux episodes and acid exposure in GERD patients unresponsive to PPI treatment. ARMS also decreased transient lower esophageal sphincter relaxations (TLESRs) and reflux symptoms without impacting esophageal distensibility. These findings support ARMS as a viable option for managing PPI-refractory GERD, suggesting a potential mechanism through the reduction of TLESRs.

Clinical Trial by Kuipers T, Oude Nijhuis RAB, Pouw RE and Bredenoord AJ in Endoscopy

The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

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Adjuvant Chemotherapy Benefits Post-Pancreaticoduodenectomy

Adjuvant therapy following pancreaticoduodenectomy for pancreatic adenocarcinoma shows improved overall survival. Patients who responded favorably to neoadjuvant therapy may not benefit from additional adjuvant treatment. Downstaging after neoadjuvant therapy is a key factor in determining the efficacy of adjuvant therapy post-surgery. The study highlights the importance of personalized treatment strategies based on individual patient responses to neoadjuvant therapy.

Journal Article by Carpenter EL, Van Decar SG (…) Vreeland TJ et 10 al. in J Surg Oncol

© 2024 Wiley Periodicals LLC.

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