Category: HPB & Spleen

Arterial Divestment Techniques for Locally Advanced Pancreatic Cancer

Utilizing periarterial and sub-adventitial divestment alongside the triangle operation and RAMPS, researchers achieved R0 resection in locally advanced pancreatic body cancer without compromising oncologic outcomes. The technique, demonstrated in a multimedia article, provides an alternative to morbid arterial resection, ensuring optimal tumor clearance and preserving patient outcomes. Journal Article by Kumar NAN, Palod A, Usman […]

Comparing Liver Transplant and Resection for Multifocal Hepatocellular Carcinoma

Study compares long-term outcomes of liver transplant (LT) and resection (LR) in patients with multifocal hepatocellular carcinoma (MHCC). LT associated with improved survival over LR, with LT patients more likely to be non-Hispanic white, privately insured, and treated at academic centers. Findings suggest LT may be the preferable surgical option for MHCC, with implications for […]

Deep Learning Improves Prediction of Response to Neoadjuvant Chemotherapy in Colorectal Liver Metastasis

Deep learning models applied to prechemotherapy imaging accurately predict response to neoadjuvant chemotherapy in colorectal cancer liver metastases, outperforming clinical models. A study on 95 patients found the deep learning model had an AUC of 0.77, superior to the clinical model’s AUC of 0.41, showing potential to identify nonresponders and guide patient management towards curative […]

Criteria for Early Drain Removal after Hepatectomy

Identifying predictors of bile leakage after hepatectomy, researchers established criteria for safe early drain removal. Analyzing 351 patients, they found a drainage fluid direct bilirubin level cutoff of 0.16 mg/dl and volume cutoff of 125 ml on postoperative day 2. Patients meeting both criteria had no leakage. These findings offer a novel approach for timely […]

Factors Influencing Long-Term Survival After Pancreatic Ductal Adenocarcinoma Resection

Improved systemic therapy has increased long-term survival rates after resection of pancreatic ductal adenocarcinoma. Sex, BMI, tumor markers, and pathological characteristics influence long-term survival. No single factor can predict survival, highlighting the complex interplay between risk, biology, and patient management. A systematic review analyzing 25 studies with 27,091 patients identifies key predictors for long-term survival […]

Robotic Pancreaticoduodenectomy Benefits for Pancreatic Cancer Patients

Robotic pancreaticoduodenectomy (RPD) offers similar or superior outcomes compared to open approaches for pancreatic ductal adenocarcinoma (PDAC) treatment. RPD shows reduced blood loss, lower post-operative pain, and shorter hospital stays. Despite similar operative times, RPD yields better oncological results, including margin status and survival rates. With increasing experience, RPD is poised to become the preferred […]

Oligo-like Liver Metastasis: Prognostic Indicator in Pancreatic Cancer

Patients with “oligo-like liver metastasis” (OLLM) in post-surgical pancreatic cancer have better overall survival after recurrence through surgical intervention. Key factors defining OLLM include long recurrence-free interval, stable disease interval, and fewer recurrent tumors. OLLM patients show significantly improved prognosis compared to non-OLLM patients, suggesting OLLM as a potential prognostic indicator for post-recurrence survival and […]

Machine Learning Prediction of Liver and Lung Metastasis in Colorectal Cancer

Using a machine learning model, researchers accurately predicted liver and/or lung metastasis in colorectal cancer patients, assisting clinical decision-making. A total of 51,265 patients were analyzed, with 15.3% having distant metastasis. The random forest algorithm showed the best predictive ability with high accuracy, AUC, and AUPR values, validated in an external set, providing a valuable […]

Identification of Potential Diagnostic Markers for Pancreatic Cancer

Plasma levels of specific miRNAs and proteins show promise as biomarkers for distinguishing between chronic pancreatitis and pancreatic adenocarcinoma, with high diagnostic performance values. The combination of miRNAs hsa-mir-150-3p, hsa-mir-150-5p, and hsa-mir-214-3p, along with proteins PCDH1 and AMN, could aid in predicting pancreatic adenocarcinoma in patients with chronic pancreatitis. Journal Article by Gong J, Zhang […]